Liquiritin/甘草苷
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货号：A215530
同义名：
Liquiritoside; Liquiritigenin-4'-O-glucoside
Liquiritin是从甘草中提取的类黄酮，对 AKR1C1、AKR1C2 和 AKR1C3 的 IC50 分别为 0.62 μM、0.61 μM 和 3.72 μM，具有抗氧化、抗炎和神经保护活性，还能抑制 AKR1C1 介导的孕酮代谢，适用于抗癌和神经退行性疾病研究。
Liquiritin/甘草苷 化学结构
Liquiritin/甘草苷 3D分子结构
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Liquiritin/甘草苷 纯度/质量文件 产品仅供科研
货号：A215530
标准纯度：
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Liquiritin/甘草苷 质控信息
Liquiritin/甘草苷 生物活性
描述
Liquiritin, a major constituent of Glycyrrhiza Radix, has various pharmacological activities, including anticancer. In vivo , liquiritin improved UVB-induced skin injury through reducing the release of pro-inflammatory cytokines[4] In vitro , when applied in single therapy, liquiritin could moderately inhibit the proliferation and migration of cisplatin (DDP)-resistant gastric cancer cells, SGC7901/DDP[3] [5]
Liquiritin/甘草苷 参考文献
[1] Wei Y, La L, et al. Paeoniflorin and liquiritin, two major constituents in Chinese herbal formulas used to treat hyperprolactinemia-associated disorders, inhibits prolactin secretion in prolactinoma cells by different mechanisms. J Ethnopharmacol. 2017 May 23;204:36-44.
[2] Sun S, Chen Q, et al. Pharmacokinetic interaction of aconitine, liquiritin and 6-gingerol in a traditional Chinese herbal formula, Sini Decoction. Xenobiotica. 2017 Jan 25:1-8.
[3] Wei F, Jiang X, Gao HY, Gao SH. Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo. Int J Oncol. 2017 Nov;51(5):1383-1394. doi: 10.3892/ijo.2017.4134. Epub 2017 Sep 22. PMID: 29048624; PMCID: PMC5642394.
[4] Li XQ, Cai LM, Liu J, Ma YL, Kong YH, Li H, Jiang M. Liquiritin suppresses UVB‑induced skin injury through prevention of inflammation, oxidative stress and apoptosis through the TLR4/MyD88/NF‑κB and MAPK/caspase signaling pathways. Int J Mol Med. 2018 Sep;42(3):1445-1459. doi: 10.3892/ijmm.2018.3720. Epub 2018 Jun 5. PMID: 29901082; PMCID: PMC6089709.
[5] Teng L, Meng Q, Lu J, Xie J, Wang Z, Liu Y, Wang D. Liquiritin modulates ERK‑ and AKT/GSK‑3β‑dependent pathways to protect against glutamate‑induced cell damage in differentiated PC12 cells. Mol Med Rep. 2014 Aug;10(2):818-24. doi: 10.3892/mmr.2014.2289. Epub 2014 May 30. PMID: 24888902; PMCID: PMC4094771.
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Liquiritin/甘草苷 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.39mL
0.48mL
0.24mL
11.95mL
2.39mL
1.20mL
23.90mL
4.78mL
2.39mL
Liquiritin/甘草苷 技术信息
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