Liquiritin

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Chemical Structure| 551-15-5 同义名 : Liquiritoside; Liquiritigenin-4'-O-glucoside; Likviritin
CAS号 : 551-15-5
货号 : A215530
分子式 : C21H22O9
纯度 : 99%
分子量 : 418.39
MDL号 : MFCD00210526
存储条件:

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 145 mg/mL(346.56 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

生物活性
描述 Liquiritin, a major constituent of Glycyrrhiza Radix, has various pharmacological activities, including anticancer. In vivo, liquiritin improved UVB-induced skin injury through reducing the release of pro-inflammatory cytokines[4]. In vitro, when applied in single therapy, liquiritin could moderately inhibit the proliferation and migration of cisplatin (DDP)-resistant gastric cancer cells, SGC7901/DDP[3]. Moreover, liquiritin (25 or 50 μM) protects DPC12 cells from glutamate-induced apoptotic cell damage[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.39mL

0.48mL

0.24mL

11.95mL

2.39mL

1.20mL

23.90mL

4.78mL

2.39mL

参考文献

[1]Wei Y, La L, et al. Paeoniflorin and liquiritin, two major constituents in Chinese herbal formulas used to treat hyperprolactinemia-associated disorders, inhibits prolactin secretion in prolactinoma cells by different mechanisms. J Ethnopharmacol. 2017 May 23;204:36-44.

[2]Sun S, Chen Q, et al. Pharmacokinetic interaction of aconitine, liquiritin and 6-gingerol in a traditional Chinese herbal formula, Sini Decoction. Xenobiotica. 2017 Jan 25:1-8.

[3]Wei F, Jiang X, Gao HY, Gao SH. Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo. Int J Oncol. 2017 Nov;51(5):1383-1394. doi: 10.3892/ijo.2017.4134. Epub 2017 Sep 22. PMID: 29048624; PMCID: PMC5642394.

[4]Li XQ, Cai LM, Liu J, Ma YL, Kong YH, Li H, Jiang M. Liquiritin suppresses UVB‑induced skin injury through prevention of inflammation, oxidative stress and apoptosis through the TLR4/MyD88/NF‑κB and MAPK/caspase signaling pathways. Int J Mol Med. 2018 Sep;42(3):1445-1459. doi: 10.3892/ijmm.2018.3720. Epub 2018 Jun 5. PMID: 29901082; PMCID: PMC6089709.

[5]Teng L, Meng Q, Lu J, Xie J, Wang Z, Liu Y, Wang D. Liquiritin modulates ERK‑ and AKT/GSK‑3β‑dependent pathways to protect against glutamate‑induced cell damage in differentiated PC12 cells. Mol Med Rep. 2014 Aug;10(2):818-24. doi: 10.3892/mmr.2014.2289. Epub 2014 May 30. PMID: 24888902; PMCID: PMC4094771.