Evaluate the inhibitory effect of Licochalcone C on CYP3A, showing time-dependent inhibition with IC50 decreasing from 6.02 μM to 2.51 μM
Acta Pharmacol Sin. 2022 Apr;43(4):1072-1081
H9c2 cells
1–250 µM
24 hours
To evaluate the inhibitory effect of LicoC on LPS-induced ROS generation, results showed that LicoC significantly reduced intracellular ROS accumulation.
Int J Mol Sci. 2017 Mar 23;18(4):690
H9c2 cells
25 µM
24 hours
To evaluate the protective effect of LicoC against LPS-induced cytotoxicity, results showed that LicoC significantly protected cells from LPS-induced cell death.
Int J Mol Sci. 2017 Mar 23;18(4):690
H9c2 cells
1–500 µM
48 hours
To evaluate the effect of LicoC on H9c2 cell viability, results showed no significant effect on cell viability at concentrations up to 250 µM.
Int J Mol Sci. 2017 Mar 23;18(4):690
HSC3 cells
10, 20, 30 µM
24 and 48 hours
LCH reduced the viability of HSC3 cells and induced cell cycle arrest and apoptosis.
Oncol Rep. 2019 Jan;41(1):333-340
HSC2 cells
10, 20, 30 µM
24 and 48 hours
LCH reduced the viability of HSC2 cells and induced cell cycle arrest and apoptosis.
Oncol Rep. 2019 Jan;41(1):333-340
JB6 cells
5, 10, 20 μM
24 or 48 hours
To evaluate the antiproliferative effect of LCC on JB6 cells, results showed that LCC did not exhibit noticeable cytotoxicity at 20 μM.
Biomol Ther (Seoul). 2024 Jan 1;32(1):104-114
HaCaT cells
5, 10, 20 μM
24 or 48 hours
To evaluate the antiproliferative effect of LCC on HaCaT cells, results showed that LCC did not exhibit noticeable cytotoxicity at 20 μM.
Biomol Ther (Seoul). 2024 Jan 1;32(1):104-114
HCT116-OxR cells
5, 10, 20 μM
24 or 48 hours
To evaluate the antiproliferative effect of LCC on HCT116-OxR cells, results showed that LCC inhibited cell growth in a concentration- and time-dependent manner.
Biomol Ther (Seoul). 2024 Jan 1;32(1):104-114
HCT116 cells
5, 10, 20 μM
24 or 48 hours
To evaluate the antiproliferative effect of LCC on HCT116 cells, results showed that LCC inhibited cell growth in a concentration- and time-dependent manner.
Biomol Ther (Seoul). 2024 Jan 1;32(1):104-114
JB6
4, 8, 12 µM
24 or 48 hours
LCH did not show cytotoxicity in JB6 cells.
Biomol Ther (Seoul). 2023 Nov 1;31(6):661-673
HaCaT
4, 8, 12 µM
24 or 48 hours
LCH did not show cytotoxicity in HaCaT cells.
Biomol Ther (Seoul). 2023 Nov 1;31(6):661-673
HCT116-OxR
4, 8, 12 µM
24 or 48 hours
LCH significantly inhibited cell viability and colony growth in HCT116-OxR cells and induced apoptosis.
Biomol Ther (Seoul). 2023 Nov 1;31(6):661-673
HCT116
4, 8, 12 µM
24 or 48 hours
LCH significantly inhibited cell viability and colony growth in HCT116 cells and induced apoptosis.
Biomol Ther (Seoul). 2023 Nov 1;31(6):661-673
Vero
27.7 mg/mL
24 hours
Evaluate the cytotoxicity of Licochalcone C on Vero cells
Front Microbiol. 2019 Nov 5;10:2489
HepG2
50.8 mg/mL
24 hours
Evaluate the cytotoxicity of Licochalcone C on HepG2 cells
Front Microbiol. 2019 Nov 5;10:2489
THP-1 (human myelomonocytic leukemia cells)
50 μM
24 hours
To evaluate the antioxidant effects of Licochalcone C on LPS and IFN-γ-induced inflammatory responses. Results showed that Licochalcone C significantly decreased the expression and activity of iNOS via the NF-κB pathway, reduced superoxide anion (O2−) production, and modulated the antioxidant network activity of SOD, CAT, and GPx.
Pharmaceuticals (Basel). 2024 May 14;17(5):634
THP-1 (human myelomonocytic leukemia cells)
50 μM
24 hours
To evaluate the antioxidant effects of Licochalcone C on LPS and IFN-γ-induced inflammatory responses. Results showed that Licochalcone C significantly decreased the expression and activity of iNOS via the NF-κB pathway, reduced superoxide anion (O2−) production, and modulated the antioxidant network activity of SOD, CAT, and GPx.
Molecules. 2011 Jul 6;16(7):5720-34
MRSA T144
4 mg/mL
Evaluate the antibacterial activity of Licochalcone C against MRSA T144
Front Microbiol. 2019 Nov 5;10:2489
MSSA ATCC29213
4 mg/mL
Evaluate the antibacterial activity of Licochalcone C against MSSA ATCC29213
搜索
