Idebenone | CV-2619;Mnesis;Catena, Raxone, Sovrima | Iron death Inhibitor | ROS

首页 / / / / Idebenone/艾地苯醌

Idebenone/艾地苯醌 {[allProObj[0].p_purity_real_show]}

货号：A249566 同义名： CV-2619; Mnesis

Idebenone是辅酶Q10（CoQ10）的合成类似物，能保护线粒体膜免受脂质过氧化，同时作为神经保护剂使用。

Idebenone/艾地苯醌化学结构
CAS号：58186-27-9

Idebenone/艾地苯醌 3D分子结构
CAS号：58186-27-9

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]} {[ getRatePriceInt(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]} {[ getRatePriceInt(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePriceInt(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price, item.pr_am) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate,item.mem_isinteger) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate,item.mem_isinteger) ]}	现货	1周咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

Idebenone/艾地苯醌纯度/质量文件产品仅供科研

货号：A249566 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]; • Cell, 2025. Ambeed. [ A122167 ]; • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]; • Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]; 更多 >

Idebenone/艾地苯醌生物活性

描述	Idebenone is a synthetic variant of coenzyme Q10 (CoQ10), which targets mitochondria, preserves mitochondrial function, and confers cytoprotection. In this way, idebenone has neuroprotective effects and has applications in Friedreich ataxia.

Idebenone/艾地苯醌细胞实验

Cell Line Neonatal rat cardiomyocytes (NRCMs)	Concentration	Treated Time	Description	References
Neonatal rat cardiomyocytes (NRCMs)	5 μM	24 h	To evaluate the protective effect of idebenone on DOX-induced cardiomyocyte toxicity, results showed that idebenone significantly improved the viability of DOX-treated cardiomyocytes.	Acta Pharm Sin B. 2024 Jun;14(6):2581-2597.

Idebenone/艾地苯醌动物实验

Species C57BL/6J male mice Drosophila C57BL/6J mice	Animal Model DOX-induced cardiotoxicity model Transgenic Drosophila expressing uN2CpolyG CCl4-induced liver fibrosis model	Administration	Dosage	Frequency	Description	References
C57BL/6J male mice	DOX-induced cardiotoxicity model	Oral gavage	200 mg/kg	Once daily for 7 days	To evaluate the protective effect of idebenone on DOX-induced cardiotoxicity, results showed that idebenone significantly improved DOX-induced cardiac dysfunction and survival rate.	Acta Pharm Sin B. 2024 Jun;14(6):2581-2597.
Drosophila	Transgenic Drosophila expressing uN2CpolyG	Oral	7, 15, 50 μM	Three times per week for 20 days	To evaluate the effect of idebenone on motor performance, lifespan, and mitochondrial function in transgenic flies, results showed that 15μM idebenone significantly improved motor performance, extended lifespan, and restored ATP synthesis levels.	Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2208649119
C57BL/6J mice	CCl4-induced liver fibrosis model	Intragastric administration	50, 100 or 200 mg/kg	Daily administration for 4 weeks	Evaluate the therapeutic effect of IDE on liver fibrosis, results showed IDE significantly reduced liver inflammation and collagen accumulation	Cell Death Dis. 2024 Aug 20;15(8):602

Idebenone/艾地苯醌临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03014856	-		Completed	-	-
NCT00224640	Friedreich Ataxia	Phase 1 Phase 2	Completed	-	France ... 展开 >> Necker Hospital Paris, France, 75015 收起 <<
NCT03014908	-		Completed	-	Belgium ... 展开 >> Hasselt University Hasselt, Limburg, Belgium, 3500 收起 <<

Idebenone/艾地苯醌参考文献

[1]Rego AC, Santos MS, Oliveira CR. Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress. Free Radic Biol Med. 1999 Jun;26(11-12):1405-17.

[2]Yamada K, Tanaka T, et al. Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci. 1999 Jan;11(1):83-90.

Idebenone/艾地苯醌实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.30mL

14.77mL

2.95mL

1.48mL

29.55mL

5.91mL

2.95mL

Idebenone/艾地苯醌技术信息

CAS号	58186-27-9
分子式	C₁₉H₃₀O₅
分子量	338.44
SMILES Code	O=C1C(CCCCCCCCCCO)=C(C)C(C(OC)=C1OC)=O
MDL No.	MFCD00274552

别名	CV-2619; Mnesis; Catena, Raxone, Sovrima
运输	蓝冰
InChI Key	JGPMMRGNQUBGND-UHFFFAOYSA-N
Pubchem ID	3686

存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry,2-8°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(310.25 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

方案三

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03014856	-		Completed	-	-
NCT00224640	Friedreich Ataxia	Phase 1 Phase 2	Completed	-	France ... 展开 >> Necker Hospital Paris, France, 75015 收起 <<
NCT03014908	-		Completed	-	Belgium ... 展开 >> Hasselt University Hasselt, Limburg, Belgium, 3500 收起 <<
NCT01421381	-		Completed	-	Canada, Quebec ... 展开 >> Hôpital Notre-Dame (CHUM) Montreal,, Quebec, Canada, H2L 4M1 Germany Friedrich Baur Institut Neurologische Klinik und Poliklinik München, Germany, D-80336 United Kingdom Biomedical Research Centre, The Medical School Newcastle upon Tyne, United Kingdom, NE2 4HH 收起 <<
NCT02774005	Leber's Hereditary Optic Neuro... 展开 >>pathy (LHON) 收起 <<	Phase 4	Recruiting	February 2021	-
NCT01495715	Leber's Hereditary Optic Neuro... 展开 >>pathy 收起 <<	Phase 3	Withdrawn	-	-
NCT00015808	Friedreich Ataxia	Phase 1	Completed	-	United States, Maryland ... 展开 >> National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland, United States, 20892 收起 <<
NCT02887443	Drug-Drug Interaction	Phase 1	Completed	-	France ... 展开 >> Eurofins Optimed Gières, France, 38610 收起 <<
NCT00078481	Friedreich Ataxia	Phase 1	Completed	-	United States, Maryland ... 展开 >> National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland, United States, 20892 收起 <<
NCT00654784	Duchenne Muscular Dystrophy (D... 展开 >>MD) 收起 <<	Phase 2	Completed	-	Belgium ... 展开 >> Children's Hospital, University Hospital Leuven, Belgium 收起 <<
NCT02771379	-		Recruiting	February 2021	Austria ... 展开 >> Universitaetsklinikum Graz Recruiting Graz, Austria, 8036 Principal Investigator: Mona Schneider, MD Medical University of Vienna Recruiting Vienna, Austria Principal Investigator: Berthold Pemp, MD France CHU de Nîmes - Hôpital Carémeau Recruiting Nîmes, Gard, France, 30029 Principal Investigator: Luc Jeanjean, MD CHU Angers - Hôpital Hôtel Dieu Recruiting Angers, Maine Et Loire, France, 49033 Principal Investigator: Christophe Verny, MD Hopital Roger Salengro - CHU Lille Recruiting Lille, Nord, France, 59037 Principal Investigator: Sabine Defoort Delemmes, MD Hôpital Européen Georges Pompidou Recruiting Paris, Paris Cedex 15, France, 75908 Principal Investigator: Christophe Orssaud, MD CHU Amiens - Centre Saint Victor Recruiting Amiens, Somme, France, 80054 Principal Investigator: Solange Milazzo, MD Hopital Neurologique Pierre Wertheimer Recruiting Lyon Cedex, France, 69677 Principal Investigator: Damien Biotti, MD Hospices Civils de Lyon Recruiting Lyon, France, 69002 Principal Investigator: Caroline Tilikete, MD Centre Hospitalier National d'Ophtalmologie (CHNO) des Quinze-Vingts Recruiting Paris, France, 75012 Principal Investigator: Catherine Vignal, MD Fondation Ophtalmologique Adolphe de Rothschild Recruiting Paris, France, 75019 Principal Investigator: Rabih Hage, MD Germany Julius Maximilians University Recruiting Wuerzburg, Baden Wuerttemberg, Germany, 97070 Principal Investigator: Thomas Ach, MD Charite - Campus Virchow-Klinikum Recruiting Berlin, Germany, 13353 Principal Investigator: Uwe Pleyer, MD Universitaetsklinikum Essen Recruiting Essen, Germany Principal Investigator: Michael Oeverhaus, MD Universitaetsklinikum Freiburg Recruiting Freiburg, Germany Principal Investigator: Wolf Lagreze Universitaetsklinikum Hamburg-Eppendorf Recruiting Hamburg, Germany, 20246 Principal Investigator: Martin Spitzer, MD Universitaetsklinikum Heidelberg Recruiting Heidelberg, Germany Principal Investigator: Klaus Rohrschneider, MD Friedrich-Baur-Institut Recruiting Munich, Germany Principal Investigator: Thomas Klopstock Universitaetsklinikum Muenster Recruiting Munster, Germany Principal Investigator: Nicole Eter, MD Universitaetsklinikum Neubrandenburg Recruiting Neubrandenburg, Germany Principal Investigator: Herbert Jaegle, MD Universitaetsklinikum Regensburg Recruiting Regensburg, Germany Principal Investigator: Helmut Hoeh, MD Greece Athens Ophthalmological Center Recruiting Athens, Greece, 11528 Principal Investigator: Agathi Kouri, MD Italy Università di Bologna-Clinica Neurologica-Dipartimento di Scienze Neurologiche Not yet recruiting Bologna, Italy, 40123 Principal Investigator: Valerio Carelli, MD Ospedale San Raffaele Recruiting Milano, Italy, 20132 Principal Investigator: Francesco Maria Bandello, MD Azienda Ospedaliera S. Camillo Forlanini Not yet recruiting Rome, Italy, 00152 Principal Investigator: Anna De Negri, MD Netherlands Universitair Medisch Centrum Groningen Recruiting Groningen, Netherlands, 9713 GZ Principal Investigator: Jan-Willem Pott, MD Maastricht University Medical Center Not yet recruiting Maastricht, Netherlands, 6211 LK Principal Investigator: Noël Bauer, MD 收起 <<
NCT01854359	Multiple Sclerosis ... 展开 >> Primary Progressive Multiple Sclerosis 收起 <<	Phase 1 Phase 2	Active, not recruiting	August 1, 2019	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT00537680	Friedreich's Ataxia	Phase 3	Completed	-	United States, California ... 展开 >> David Geffen School of Medicine, UCLA Los Angeles, California, United States, 90095-1769 United States, Pennsylvania The Children's Hopsital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT00654784	-		Completed	-	-
NCT00950248	Primary Progressive Multiple S... 展开 >>clerosis 收起 <<	Phase 1 Phase 2	Completed	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT00537680	-		Completed	-	-
NCT00229632	Friedreich Ataxia	Phase 2	Completed	-	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT00747487	Leber's Hereditary Optic Neuro... 展开 >>pathy 收起 <<	Phase 2	Completed	-	Canada, Quebec ... 展开 >> Unité de recherche clinique Ophtalmologie- Hopital Notre-Dame Montreal, Quebec, Canada, H2L 4M1 Germany Klinikum der Universität München - Grosshadern, Neurologische Klinik und Poliklinik Munich, Germany, 81377 United Kingdom Clinical Research Facility, 4th Floor Leazes Wing, Royal Victoria Infirmary Newcastle Upon Tyne, United Kingdom, NE1 4LP 收起 <<
NCT02814019	Duchenne Muscular Dystrophy (D... 展开 >>MD) 收起 <<	Phase 3	Recruiting	August 2019	-
NCT00905268	-		Completed	-	-
NCT00697073	Friedreich's Ataxia	Phase 3	Completed	-	United States, California ... 展开 >> David Geffen School of Medicine, UCLA Los Angeles, California, United States, 90095-1769 United States, Pennsylvania The Children's Hopsital of Philadelphia Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT00697073	-		Completed	-	-
NCT01027884	Muscular Dystrophy, Duchenne ... 展开 >> Ambulatory Care 收起 <<	Phase 3	Completed	-	-
NCT01027884	-		Completed	-	-
NCT00905268	Friedreich's Ataxia	Phase 3	Completed	-	Austria ... 展开 >> Universitätsklinik Innsbruck Innsbruck, Austria, 6020 Belgium Hôpital Erasme - Université Libre de Bruxelles Bruxelles, Belgium, 1070 France Hôpital de la Salpêtrière - INSERM U679, Neurologie et Thérapeutique expérimentale Paris, France, 75651 Germany HELIOS Klinikum BerlinBuch Berlin, Germany, 13125 Neurologische Universitätsklinik und Poliklinik- Universitätsklinikum Bonn Bonn, Germany, 53105 Klinik II, Neuropädiatrie u.Muskelerkrankungen- Universitätsklinik Freiburg Freiburg, Germany, 79106 Zentrum für Neurologische Medizin Göttingen, Germany, 37073 UKE Hamburg Neuropädiatrie-Zentum für Frauen, Kinder und Jugendmedizin Hamburg, Germany, 20246 Neurologische Klinik- klinikum Grosshadern München, Germany, 81377 Neurologische Universitätsklinik und Poliklinik Tübingen, Germany, 72076 Netherlands University Medical Center Groningen Groningen, Netherlands, 9700 RB United Kingdom National Hospital for Neurology & Neurosurgery London, United Kingdom, WC1N 3BG University of Newcastle upon Tyne -Mitochondrial Research Group Newcastle, United Kingdom, NE2 4HH 收起 <<
NCT00993967	Freidreich's Ataxia	Phase 3	Completed	-	Austria ... 展开 >> Universitätsklinik Innsbruck Innsbruck, Austria Belgium Hôpital Erasme - Univeristé Libre de Bruxelles Bruxelles, Belgium, 1070 France Hôpital de la Salpétrière - INSERM U679, Neurologie et Thérapeutique expérimentale Paris, France, 75651 Germany HELIOS Klinikum Berlin Berlin, Germany, 13125 Neurologische Universitätsklinik und Ploklinik - Universitätsklimikum Bonn Bonn, Germany, 53105 Klinik II, Neuropädiatrie und Muskelerkrankungen - Universitätsklinik Freiburg Freiburg, Germany, 79106 Zentrum für Neurologische Medizin Göttingen, Germany, 37073 UKE Hamburg Neuropädiatrie - Zentrum für Frauen, Kinder und Jugendmedizin Hamburg, Germany, 20246 Neurologische Klinik - Klinikum Grosshadern München, Germany, 81377 Neurologische Universitätsklinik und Poliklinik Tübingen, Germany, 72076 Netherlands University medical Center Groningen Groningen, Netherlands, 9700 RB 收起 <<
NCT00758225	Duchenne Muscular Dystrophy	Phase 2	Completed	-	Belgium ... 展开 >> University Hospitals Leuven Leuven, Belgium, 3000 收起 <<
NCT00887562	-		Completed	-	-
NCT00993967	-		Completed	-	-
NCT03727295	Oxidative Stress is an Importa... 展开 >>nt Cause of Parkinson's Disease 收起 <<	Phase 4	Not yet recruiting	May 30, 2021	-
NCT01303406	Friedreich's Ataxia	Phase 3	Completed	-	Austria ... 展开 >> Innsbruck, Austria Germany Bonn, Germany München, Germany Tübingen, Germany Netherlands Groningen, Netherlands United Kingdom The National Hospital, University College London London, United Kingdom, WC 1N 3BG 收起 <<
NCT03433807	-		-	-	United States, Arizona ... 展开 >> Phoenix Children's Hospital Phoenix, Arizona, United States, 85016 Contact: Saunder Bernes, MD United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 Contact: Kathy Mathews, MD United States, Maryland Kennedy Krieger Baltimore, Maryland, United States, 21287 Contact: Kathryn Wagner, MD, PhD 收起 <<
NCT00887562	MELAS Syndrome	Phase 2	Completed	-	United States, New York ... 展开 >> Columbia University Medical Center New York, New York, United States, 10032 收起 <<
NCT03603288	Duchenne Muscular Dystrophy	Phase 3	Recruiting	January 2022	United States, Minnesota ... 展开 >> Gillette Children's Specialty Healthcare Recruiting Saint Paul, Minnesota, United States, 55101 Contact: Randel Richardson, MD Belgium University Hospital Leuven Recruiting Leuven, Belgium, 3000 Contact: Gunnar Buyse, MD Principal Investigator: Gunnar Buyse, MD CHR Citadelle Recruiting Liège, Belgium, 4000 Principal Investigator: Laurent Servais, MD Italy Fondazione IRCCS Eugenio Medea Recruiting Bosisio Parini, Italy, 23842 Contact: Maria Grazia Nadia D'Angelo, MD Principal Investigator: Maria Grazia Nadia D'Angelo, MD Switzerland Center for neuromuscular disorders, Universitäts-Kinderspital beider Basel (UKBB) Recruiting Basel, Switzerland, 4301 Principal Investigator: Andrea Klein, MD United Kingdom Robert Jones and Agnes Hunt Orthopaedic Hospital Recruiting Oswestry, United Kingdom, SY10 7AG Contact: Tracey Willis, MD Principal Investigator: Tracey Willis, MD 收起 <<
NCT01303406	-		Completed	-	-

Idebenone/艾地苯醌 {[allProObj[0].p_purity_real_show]}

Idebenone/艾地苯醌纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Idebenone/艾地苯醌质控信息

Idebenone/艾地苯醌生物活性

Idebenone/艾地苯醌细胞实验

Idebenone/艾地苯醌动物实验

Idebenone/艾地苯醌临床研究

Idebenone/艾地苯醌参考文献

Idebenone/艾地苯醌实验方案

Idebenone/艾地苯醌技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Idebenone/艾地苯醌 {[allProObj[0].p_purity_real_show]}

Idebenone/艾地苯醌 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Idebenone/艾地苯醌 质控信息

Idebenone/艾地苯醌 生物活性

Idebenone/艾地苯醌 细胞实验

Idebenone/艾地苯醌 动物实验

Idebenone/艾地苯醌 临床研究

Idebenone/艾地苯醌 参考文献

Idebenone/艾地苯醌 实验方案

Idebenone/艾地苯醌 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Idebenone/艾地苯醌纯度/质量文件产品仅供科研

Idebenone/艾地苯醌质控信息

Idebenone/艾地苯醌生物活性

Idebenone/艾地苯醌细胞实验

Idebenone/艾地苯醌动物实验

Idebenone/艾地苯醌临床研究

Idebenone/艾地苯醌参考文献

Idebenone/艾地苯醌实验方案

Idebenone/艾地苯醌技术信息