Idebenone

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Chemical Structure| 58186-27-9 同义名 : CV-2619; Mnesis; Catena, Raxone, Sovrima
CAS号 : 58186-27-9
货号 : A249566
分子式 : C19H30O5
纯度 : 98%
分子量 : 338.44
MDL号 : MFCD00274552
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(310.25 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Idebenone is a synthetic variant of coenzyme Q10 (CoQ10), which targets mitochondria, preserves mitochondrial function, and confers cytoprotection. In this way, idebenone has neuroprotective effects and has applications in Friedreich ataxia.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03014856 - Completed - -
NCT00224640 Friedreich Ataxia Phase 1 Phase 2 Completed - France ... 展开 >> Necker Hospital Paris, France, 75015 收起 <<
NCT03014908 - Completed - Belgium ... 展开 >> Hasselt University Hasselt, Limburg, Belgium, 3500 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.30mL

14.77mL

2.95mL

1.48mL

29.55mL

5.91mL

2.95mL
参考文献

[1]Rego AC, Santos MS, Oliveira CR. Influence of the antioxidants vitamin E and idebenone on retinal cell injury mediated by chemical ischemia, hypoglycemia, or oxidative stress. Free Radic Biol Med. 1999 Jun;26(11-12):1405-17.

[2]Yamada K, Tanaka T, et al. Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci. 1999 Jan;11(1):83-90.