There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Hygromycin B is an aminocyclitol antibiotic that strongly inhibits both 70S and 80S ribosomes, produced by streptomyces hygroscopicus. Hygromycin B inhibits protein synthesis in archaebacteria, eubacteria, fungi, and higher eukaryotes[3]. in vitro，hygromycin B at 0.38 mM concentration completely halts yeast cell growth in rich media, presumably by preventing protein synthesis by cytoplasmic ribosomes[4]. in vivo，hygromycin B inhibits protein synthesis by blocking ribosomal translocation without causing significant misreading[3]. In eukaryotes, the antibiotic affects EF-2-mediated translocation of A site bound tRNA to the P site. The inhibition of translocation is accompanied by an increase in the affinity of the A site for aminoacyl-tRNA[5].
体内研究
To detect antiviral activity in vivo, Hygromycin B (0-5 μmoL/kg) was administered intraperitoneally to MHV-A59-infected BALB/c mice twice daily for three days.Hygromycin B was able to reduce the level of viral replication and necrotic liver foci in vivo[6].
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HazMat Fee +
