Human VEGFB (N-Fc, HEK293)/人VEGFB蛋白(N-Fc, HEK293)
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货号：A2925267同义名：
重组人VEGFB蛋白(N-Fc, HEK293)
/ Recombinant Human VEGFB (N-Fc, HEK293); Vascular endothelial growth factor B
Recombinant Human VEGFB (N-Fc, HEK293)是人源蛋白，在HEK293人源细胞中表达，带有N端Fc标签。该蛋白又称VRF，属于VEGF生长因子家族，具有结构与功能相似性，存在167和186个氨基酸两种亚型，主要在心脏、骨骼肌和胰腺中表达，其亚型均含半胱氨酸结VEGF同源结构域，其中VEGF-B167含高碱性肝素结合域，部分形式可结合神经纤毛蛋白-1，参与神经元导向。
Human VEGFB (N-Fc, HEK293)/人VEGFB蛋白(N-Fc, HEK293) 化学结构 CAS号：N/A
Human VEGFB (N-Fc, HEK293)/人VEGFB蛋白(N-Fc, HEK293) 3D分子结构 CAS号：N/A
Human VEGFB (N-Fc, HEK293)/人VEGFB蛋白(N-Fc, HEK293) 质控信息
Human VEGFB (N-Fc, HEK293)/人VEGFB蛋白(N-Fc, HEK293) 生物活性
描述
VEGFB, as known as VRF, is a member of the VEGF family of growth factors that share structural and functional similarity. By alternative splicing, two isoforms of mature VEGF-B containing 167 or 186 amino acid (aa) residues exist. VEGF-B is expressed in most tissues, especially in heart, skeletal muscle and pancreas. The two VEGF-B isoforms have identical amino-terminal cysteine-knot VEGF homology domains but the carboxyl end of VEGF-B167 differs from that of VEGF-B186 by the presence of a highly basic cysteine-rich heparin binding domain. VEGF-B167 and a proteolytically processed form of VEGF-B186 also bind neuropilin-1, a type I transmembrane receptor for semaphorins/collapsins, ligands involved in neuron guidance.
Lyophilized from a 0.2 μm filtered solution of 20 mM Glycine, 6% Sucrose, 5% Mannitol, 0.05% Tween80, pH3.0.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human VEGFB (N-Fc, HEK293)/人VEGFB蛋白(N-Fc, HEK293) 技术信息
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