Recombinant Human KIR2DL4 (C-6His, HEK293)是人源蛋白，在HEK293细胞中表达，带有C端6×His标签。该蛋白为杀伤细胞免疫球蛋白样受体2DL4，属于免疫球蛋白超家族，是单次跨膜I型蛋白，含2个免疫球蛋白C2型结构域，主要表达于NK细胞及部分T细胞，可激活NK细胞细胞毒性，其胞内ITIM对激活信号非必需，但受其他ITIM受体调控，激活缺陷突变体可抑制CD16信号。
Human KIR2DL4 (C-6His, HEK293)/人KIR2DL4蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Human KIR2DL4 (C-6His, HEK293)/人KIR2DL4蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Human KIR2DL4 (C-6His, HEK293)/人KIR2DL4蛋白(C-6His, HEK293) 质控信息
Human KIR2DL4 (C-6His, HEK293)/人KIR2DL4蛋白(C-6His, HEK293) 生物活性
描述
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human KIR2DL4 (C-6His, HEK293)/人KIR2DL4蛋白(C-6His, HEK293) 技术信息
CAS号
N/A
分子量
25.34 KDa
SMILES Code
NONE
别名
重组人KIR2DL4蛋白(C-6His, HEK293)
;Recombinant Human KIR2DL4 (C-6His, HEK293); Killer Cell Immunoglobulin-Like Receptor 2DL4; CD158 Antigen-Like Family Member D; G9P; Killer Cell Inhibitory Receptor 103AS; KIR-103AS; MHC Class I NK Cell Receptor KIR103AS; CD158d; KIR2DL4; CD158D; KIR103AS
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human KIR2DL4 (C-6His, HEK293)/人KIR2DL4蛋白(C-6His, HEK293)
|Human KIR2DL4 (C-6His, HEK293)/人KIR2DL4蛋白(C-6His, HEK293)
| 重组人KIR2DL4蛋白(C-6His, HEK293)
| Recombinant Human KIR2DL4 (C-6His, HEK293)
| Killer Cell Immunoglobulin-Like Receptor 2DL4
| CD158 Antigen-Like Family Member D
| G9P
| Killer Cell Inhibitory Receptor 103AS
| KIR-103AS
| MHC Class I NK Cell Receptor KIR103AS
| CD158d
| KIR2DL4
| CD158D
| KIR103AS
| N/A
| NK Cell CD Proteins
| Killer-Cell Immunoglobulin-like Receptors
| Human KIR2DL4 (C-6His, HEK293)/人KIR2DL4蛋白(C-6His, HEK293) 纯度/质量文件
| Human KIR2DL4 (C-6His, HEK293)/人KIR2DL4蛋白(C-6His, HEK293) 生物活性
| Human KIR2DL4 (C-6His, HEK293)/人KIR2DL4蛋白(C-6His, HEK293) 技术信息
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