Human KIR2DL4 (C-6His, HEK293)
产品说明书
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同义名 : | 重组人KIR2DL4蛋白(C-6His, HEK293) ;Recombinant Human KIR2DL4 (C-6His, HEK293); Killer Cell Immunoglobulin-Like Receptor 2DL4; CD158 Antigen-Like Family Member D; G9P; Killer Cell Inhibitory Receptor 103AS; KIR-103AS; MHC Class I NK Cell Receptor KIR103AS; CD158d; KIR2DL4; CD158D; KIR103AS |
| CAS号 : | N/A | |
| 货号 : | A2924344 | |
| 分子式 : | - | |
| 纯度 : | 80% determined by reducing SDS-PAGE. | |
| 分子量 : | 25.34 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16. | ||