货号:A2926260
同义名:
重组人KIR2DL1蛋白(C-6His, HEK293)
/ Recombinant Human KIR2DL1 (C-6His, HEK293); CD158 antigen-like family member A
Recombinant Human KIR2DL1 (C-6His, HEK293) 是人源KIR2DL1蛋白,在HEK293细胞中表达,带有C端6×His标签。该蛋白为抑制性自然杀伤细胞免疫球蛋白样受体,具有两个胞外免疫球蛋白结构域,可通过识别靶细胞上特定I类主要组织相容性复合体(如HLA-Cw4)下调NK细胞毒性,其相互作用通过抑制NK细胞激活及增强NK细胞自身应答能力发挥作用。


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| 描述 | Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) is an inhibitory Natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 is bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. KIR/HLA-I interactions can act through inhibition of NKC activation by target cells and NKC licensing for greater intrinsic responsiveness. |
| 蛋白种属 | Human |
| 表达系统 | Human cells |
| 标签 | C-6His |
| 蛋白表达区间 | His22-His245 |
| 蛋白编号 | P43626 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 25.5 KDa |
| SMILES Code | NONE |
| 别名 | 重组人KIR2DL1蛋白(C-6His, HEK293) ;Recombinant Human KIR2DL1 (C-6His, HEK293); CD158 antigen-like family member A; CD158a antigen; CD158a; KIR2DL1; MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT; NKAT-1; p58.1 MHC class-I-specific NK receptor |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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