Human KIR2DL1 (C-6His, HEK293)
产品说明书
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同义名 : | 重组人KIR2DL1蛋白(C-6His, HEK293) ;Recombinant Human KIR2DL1 (C-6His, HEK293); CD158 antigen-like family member A; CD158a antigen; CD158a; KIR2DL1; MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT; NKAT-1; p58.1 MHC class-I-specific NK receptor |
| CAS号 : | N/A | |
| 货号 : | A2926260 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 25.5 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) is an inhibitory Natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 is bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. KIR/HLA-I interactions can act through inhibition of NKC activation by target cells and NKC licensing for greater intrinsic responsiveness. | ||