Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293)
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货号：A2924736同义名：
重组人JAG1蛋白(C-Fc, HEK293)
/ Recombinant Human JAG1 (C-Fc, HEK293); Protein jagged-1 I
Recombinant Human JAG1 (C-Fc, HEK293)是人类JAG1蛋白，在HEK293人源细胞中表达，带有C-Fc标签。该蛋白又称Jagged-1，是单次跨膜I型蛋白，含一个DSL结构域和十六个EGF样结构域，作为Notch受体配体参与Notch信号通路调控，影响心血管发育、肌细胞分化及血管生成，其缺陷可导致Alagille综合征1型。
Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293) 质控信息
Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293) 生物活性
描述
Protein jagged-1 I, also known as Jagged-1, JAGL1, HJ1, JAG1 and CD339, is a single-pass type I membrane protein. JAG1 contains one DSL domain and sixteen EGF-like domain. JAG1 acts as a ligand for multiple Notch receptors and is involved in the mediation of Notch signaling. JAG1 may participate in early and late stages of mammalian cardiovascular development, JAG1 inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1 are the cause of Alagille syndrome type 1, which is autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293) 技术信息
CAS号
N/A
分子量
137.6 KDa
SMILES Code
NONE
别名
重组人JAG1蛋白(C-Fc, HEK293)
;Recombinant Human JAG1 (C-Fc, HEK293); Protein jagged-1 I; Jagged-1; JAGL1; HJ1; JAG1 and CD339
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293)
|Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293)
| 重组人JAG1蛋白(C-Fc, HEK293)
| Recombinant Human JAG1 (C-Fc, HEK293)
| Protein jagged-1 I
| Jagged-1
| JAGL1
| HJ1
| JAG1 and CD339
| N/A
| Epithelial cell CD Proteins
| Notch family
| Endothelial cell CD Proteins
| Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293) 纯度/质量文件
| Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293) 生物活性
| Human JAG1 (C-Fc, HEK293)/人JAG1蛋白(C-Fc, HEK293) 技术信息
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