Human JAG1 (C-Fc, HEK293)

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Chemical Structure| N/A 同义名 : 重组人JAG1蛋白(C-Fc, HEK293) ;Recombinant Human JAG1 (C-Fc, HEK293); Protein jagged-1 I; Jagged-1; JAGL1; HJ1; JAG1 and CD339
CAS号 : N/A
货号 : A2924736
分子式 : -
纯度 : 90% determined by reducing SDS-PAGE.
分子量 : 137.6 KDa
MDL号 : -
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Protein jagged-1 I, also known as Jagged-1, JAGL1, HJ1, JAG1 and CD339, is a single-pass type I membrane protein. JAG1 contains one DSL domain and sixteen EGF-like domain. JAG1 acts as a ligand for multiple Notch receptors and is involved in the mediation of Notch signaling. JAG1 may participate in early and late stages of mammalian cardiovascular development, JAG1 inhibits myoblast differentiation and enhances fibroblast growth factor-induced angiogenesis. Defects in JAG1 are the cause of Alagille syndrome type 1, which is autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations.