货号:A2926567
同义名:
重组人IL-2RA&IL-2RB异二聚体蛋白(C-6His, C-Flag, HEK293)
/ Recombinant Human IL-2RA&IL-2RB Heterodimer Protein (C-6His, C-Flag, HEK293); IL-2RA&IL-2RB Heterodimer
Recombinant Human IL-2RA&IL-2RB Heterodimer Protein (C-6His, C-Flag, HEK293) 是人源重组白细胞介素-2受体α/β异源二聚体蛋白,在人源细胞中表达,带有C端6×His和Flag双标签。该蛋白可用于免疫相关研究,适用于信号通路分析、受体功能验证及抗体筛选等实验应用。


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| 描述 | IL-2 exerts its pleiotropic activities through binding to different receptor complexes, depending on which of the components are expressed on the cell surface: the alpha chain (IL-2Ra), beta chain (IL-2Rb), and common cytokine receptor gamma chain (gc). Whereas IL-2Ra is a specific receptor for IL-2, IL-2Rb is also a component of the IL-15 receptor and gc is shared by cytokines IL-4, IL-7, IL-9, IL-15, and IL-21.IL-2Ra has been shown to deviate from typical cytokine receptor structure and mode of interaction with IL-2. Interleukin-2 receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-6His, C-Flag |
| 蛋白表达区间 | Glu22-Cys213&Ala27-Asp239 |
| 蛋白编号 | P01589, P14784 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 26.8&29.8 KDa |
| SMILES Code | NONE |
| 别名 | 重组人IL-2RA&IL-2RB异二聚体蛋白(C-6His, C-Flag, HEK293) ;Recombinant Human IL-2RA&IL-2RB Heterodimer Protein (C-6His, C-Flag, HEK293); IL-2RA&IL-2RB Heterodimer |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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