Human IL-2RA&IL-2RB Heterodimer Protein (C-6His, C-Flag, HEK293)
产品说明书
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同义名 : | 重组人IL-2RA&IL-2RB异二聚体蛋白(C-6His, C-Flag, HEK293) ;Recombinant Human IL-2RA&IL-2RB Heterodimer Protein (C-6His, C-Flag, HEK293); IL-2RA&IL-2RB Heterodimer |
| CAS号 : | N/A | |
| 货号 : | A2926567 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 26.8&29.8 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | IL-2 exerts its pleiotropic activities through binding to different receptor complexes, depending on which of the components are expressed on the cell surface: the alpha chain (IL-2Ra), beta chain (IL-2Rb), and common cytokine receptor gamma chain (gc). Whereas IL-2Ra is a specific receptor for IL-2, IL-2Rb is also a component of the IL-15 receptor and gc is shared by cytokines IL-4, IL-7, IL-9, IL-15, and IL-21.IL-2Ra has been shown to deviate from typical cytokine receptor structure and mode of interaction with IL-2. Interleukin-2 receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. | ||