货号:A2926443
同义名:
重组人IL-2 R beta&IL-2 R gamma异二聚体蛋白(C-Fc&C-Fc, HEK293)
/ Recombinant Human IL-2 R beta&IL-2 R gamma Heterodimer Protein (C-Fc, HEK293); IL-2 R beta & IL-2 R gamma,IL-2RB & IL-2RG
Recombinant Human IL-2 R beta&IL-2 R gamma Heterodimer Protein (C-Fc, HEK293) 是人源蛋白,在HEK293人源细胞中表达,带有C-Fc&C-Fc标签。该蛋白为IL-2受体的β与γ链异源二聚体,参与IL-2信号转导及受体介导的内吞作用,可高效传递IL-2的促有丝分裂信号,其结合特性优于天然IL-2,适用于免疫研究及相关药物开发。


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| 描述 | The interleukin 2 (IL-2) receptor (IL-2R) is a multisubunit receptor that includes three major IL-2 binding subunits, the IL-2R alpha, beta, and gamma chains. We have detected and analyzed cooperative interactions between the IL-2R alpha and beta chains (IL-2R alpha and IL-2R beta, respectively) in COS cells transfected with cDNAs encoding the IL-2R alpha, the IL-2R beta, or both cDNAs.The affinities of Neo-2/15 for the human and mouse IL-2 receptors (IL-2Rβ and IL-2Rβγc) are significantly higher than those of the corresponding native IL-2 cytokines. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. |
| 蛋白种属 | Human |
| 表达系统 | Human Cells |
| 标签 | C-Fc&C-Fc |
| 蛋白表达区间 | Ala27-Asp239&Leu23-Asn254 |
| 蛋白编号 | P14784, P31785 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 干粉 |
| 剂型描述 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。 分装后的蛋白在≤-20°C 下可稳定保存 1 个月。 |
| CAS号 | N/A |
| 分子量 | 54&51 KDa |
| SMILES Code | NONE |
| 别名 | 重组人IL-2 R beta&IL-2 R gamma异二聚体蛋白(C-Fc&C-Fc, HEK293) ;Recombinant Human IL-2 R beta&IL-2 R gamma Heterodimer Protein (C-Fc, HEK293); IL-2 R beta & IL-2 R gamma,IL-2RB & IL-2RG |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Sealed in dry, store in freezer, under -20°C |
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