货号:A2926113
同义名:
重组人IA2蛋白(365AA, N-6His, E.coli)
/ Recombinant Human IA2 (365AA,N-6His, E.coli); Receptor-type tyrosine-protein phosphatase-like N
Recombinant Human IA2 (365AA,N-6His, E.coli) 是人源蛋白,在大肠杆菌中表达,带有N端6×His标签。该蛋白为受体型酪氨酸蛋白磷酸酶样N(PTPRN),属于蛋白酪氨酸磷酸酶家族及受体第8亚家族,特异表达于神经内分泌细胞,参与神经内分泌分泌过程,可能调控分泌小泡的生物发生、运输或调节性外排,与胰岛素依赖型糖尿病(IDDM)自身免疫相关,有潜在研究价值。


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| 描述 | Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. |
| 蛋白种属 | Human |
| 表达系统 | E.coli |
| 标签 | N-6His |
| 蛋白表达区间 | Arg576-Gln950 |
| 蛋白编号 | Q16849 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 44.6 KDa |
| SMILES Code | NONE |
| 别名 | 重组人IA2蛋白(365AA, N-6His, E.coli) ;Recombinant Human IA2 (365AA,N-6His, E.coli); Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512 |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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