货号:A2923984
同义名:
重组人Cyclophilin A蛋白(C-6His, E.coli)
/ Recombinant Human Cyclophilin A (C-6His, E.coli); Peptidyl-prolyl cis-trans isomerase A
Recombinant Human Cyclophilin A (C-6His, E.coli) 是人源Cyclophilin A蛋白,在大肠杆菌中表达,带有C端6×His标签。该蛋白又称肽基脯氨酰异构酶A(PPIA),是一种18 kDa蛋白,可催化脯氨酸亚氨基肽键的顺反异构化,促进蛋白质折叠与转运并调节其活性。它参与炎症调控,可通过影响T细胞信号及作为白细胞趋化因子发挥作用。


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| 描述 | Cyclophilin A, also known as peptidylprolyl isomerase A (PPIA), is an 18 kDa protein that catalyzes cis-trans isomerization at proline imidic peptide bonds, thereby promoting protein folding/trafficking and regulating protein activity. Cyclophilin A has multiple known functions in inflammation. Intracellularly, cyclophilin A interacts with interleukin (IL)-2 inducible T cell kinase (ITK) to tune T cell receptor signaling. Extracellularly, cyclophilin A is known to function as a leukocyte chemotactic factor. Cells secrete cyclophilin A by a vesicular secretory pathway in response to lipopolysaccharide and oxidative stress, or cyclophilin A may be released during cell death. Cyclophilin A influences inflammatory responses through its actions on immune activation and/or leukocyte trafficking. |
| 蛋白种属 | Human |
| 表达系统 | E.coli |
| 标签 | C-6His |
| 蛋白表达区间 | Val2-Glu165 |
| 蛋白编号 | P62937 |
| 内毒素 | < 1 EU/µg as determined by LAL test. |
| 剂型 | 液体 |
| 剂型描述 | Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, 1mM DTT, pH 7.4. |
| 复溶 | 如要长期保存,建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释,如果是做无血清培养或者动物体内实验时,细胞因子中不能含有BSA、FBS 和 HAS,可以使用海藻糖作为载体,然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子,并避免反复冻融;稀释分装浓度不低于 10μg/mL,分装体积不低于10μL。分装后的蛋白在≤-20°C 下可稳定保存 3 个月。 |
| CAS号 | N/A |
| 分子量 | 18.8 KDa |
| SMILES Code | NONE |
| 别名 | 重组人Cyclophilin A蛋白(C-6His, E.coli) ;Recombinant Human Cyclophilin A (C-6His, E.coli); Peptidyl-prolyl cis-trans isomerase A; PPIA; PPIase A; Cyclosporin A-binding protein; Rotamase A; Cyclophilin A; Cyclosporin A-binding protein; CYPA |
| 运输 | 蓝冰 |
| 存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
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