Human Cyclophilin A (C-6His, E.coli)
产品说明书
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同义名 : | 重组人Cyclophilin A蛋白(C-6His, E.coli) ;Recombinant Human Cyclophilin A (C-6His, E.coli); Peptidyl-prolyl cis-trans isomerase A; PPIA; PPIase A; Cyclosporin A-binding protein; Rotamase A; Cyclophilin A; Cyclosporin A-binding protein; CYPA |
| CAS号 : | N/A | |
| 货号 : | A2923984 | |
| 分子式 : | - | |
| 纯度 : | 95% determined by reducing SDS-PAGE. | |
| 分子量 : | 18.8 KDa | |
| MDL号 : | - | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -70°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
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| 描述 | Cyclophilin A, also known as peptidylprolyl isomerase A (PPIA), is an 18 kDa protein that catalyzes cis-trans isomerization at proline imidic peptide bonds, thereby promoting protein folding/trafficking and regulating protein activity. Cyclophilin A has multiple known functions in inflammation. Intracellularly, cyclophilin A interacts with interleukin (IL)-2 inducible T cell kinase (ITK) to tune T cell receptor signaling. Extracellularly, cyclophilin A is known to function as a leukocyte chemotactic factor. Cells secrete cyclophilin A by a vesicular secretory pathway in response to lipopolysaccharide and oxidative stress, or cyclophilin A may be released during cell death. Cyclophilin A influences inflammatory responses through its actions on immune activation and/or leukocyte trafficking. | ||