Recombinant Human CEACAM5 (C-Fc, HEK293)是人类来源的重组蛋白，在HEK293人源细胞中表达，带有C-Fc标签。该蛋白即CEACAM5，又称CEA和CD66e，属于癌胚抗原相关细胞黏附分子家族，具有七个胞外Ig结构域，主要在上皮细胞中表达，通过同源及异源相互作用介导钙离子非依赖性细胞黏附，与肿瘤发生发展密切相关，常作为癌症标志物使用。
Human CEACAM5 (C-Fc, HEK293)/人CEACAM5蛋白(C-Fc, HEK293) 化学结构 CAS号：N/A
Human CEACAM5 (C-Fc, HEK293)/人CEACAM5蛋白(C-Fc, HEK293) 3D分子结构 CAS号：N/A
Human CEACAM5 (C-Fc, HEK293)/人CEACAM5蛋白(C-Fc, HEK293) 质控信息
Human CEACAM5 (C-Fc, HEK293)/人CEACAM5蛋白(C-Fc, HEK293) 生物活性
描述
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition. CEACAM5, also called CEA and CD66e, is characterized by having seven extracellular Ig domains and a glycosylphosphatidylinositol (GPI) anchor. CEACAM5 is expressed primarily by epithelial cells, and functions as a calcium-independent adhesion molecule through homophilic and heterophilic interactions with CEACAM1. Studies have shown that CEACAM5 is overexpressed in a majority of carcinomas, and its overexpression can protect tumor cells from apoptosis. It is commonly used as a cancer marker.
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CEACAM5 (C-Fc, HEK293)/人CEACAM5蛋白(C-Fc, HEK293) 技术信息
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