Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293)
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货号：A2926288同义名：
重组人CD45蛋白(C-6His, HEK293)
/ Recombinant Human CD45 (C-6His, HEK293); B220
Recombinant Human CD45 (C-6His, HEK293)是人源蛋白，在HEK293细胞中表达，带有C端6×His标签。该蛋白为蛋白酪氨酸磷酸酶受体C型（CD45/PTPRC），属于PTP家族，广泛表达于造血来源的有核细胞表面，参与调控细胞增殖、分化、有丝分裂及肿瘤转化等过程，主要在T细胞中调节TCR信号阈值，并在免疫突触中负调控LCK激酶活性，影响免疫细胞功能与存活。
Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293) 化学结构 CAS号：N/A
Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293) 3D分子结构 CAS号：N/A
Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293) 质控信息
Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293) 生物活性
描述
Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. It is a variably glycosylated 180-220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin. CD45 has several isoforms, expressed according to cell type, developmental stage and antigenic exposure. CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be fine-tuned by varying usage of the heavily O-glycosylated spliced regions and sialylation of N-linked carbohydrates. Within the IS, CD45 dephosphorylates and negatively regulates the src family kinase, LCK. In other leukocytes, CD45 influences differentiation and links immunoreceptor signaling with cytokine secretion and cell survival, partially overlapping in function with DEP-1/CD148. CD45 deletion causes in severe immunodeficiency, while point mutations may be associated with autoimmune disorders.
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
复溶
Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.如要长期保存，建议使用含载体蛋白(如 0.1%BSA、10%FBS、5%HSA)的溶液进一步稀释，如果是做无血清培养或者动物体内实验时，细胞因子中不能含有BSA、FBS 和 HAS，可以使用海藻糖作为载体，然后分装冻存于-20℃至-80℃。注:分装保存时建议使用低吸附的管子，并避免反复冻融；稀释分装浓度不低于 10μg/mL，分装体积不低于10μL。
分装后的蛋白在≤-20°C 下可稳定保存 3 个月。
Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293) 技术信息
CAS号
N/A
分子量
61.6 KDa
SMILES Code
NONE
别名
重组人CD45蛋白(C-6His, HEK293)
;Recombinant Human CD45 (C-6His, HEK293); B220; CD45 antigen; CD45; CD45R; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, C; PTPRC; receptor-type tyrosine-protein phosphatase C
运输
蓝冰
存储条件
In solvent-20°C:3-6个月-80°C:12个月
Pure formSealed in dry, store in freezer, under -20°C
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Tags:
Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293)
|Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293)
| 重组人CD45蛋白(C-6His, HEK293)
| Recombinant Human CD45 (C-6His, HEK293)
| B220
| CD45 antigen
| CD45
| CD45R
| LCA
| L-CA
| LY5
| protein tyrosine phosphatase, receptor type, C
| PTPRC
| receptor-type tyrosine-protein phosphatase C
| N/A
| Dendritic Cell CD Proteins
| Macrophage CD Proteins
| Monocyte CD Proteins
| Stem Cell CD Proteins
| T Cell CD Proteins
| Phosphatase/Recombinant Protein
| Receptor Tyrosine Phosphatase
| B Cell CD Proteins
| Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293) 纯度/质量文件
| Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293) 生物活性
| Human CD45 (C-6His, HEK293)/人CD45蛋白(C-6His, HEK293) 技术信息
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