There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Herbacetin, a natural product isolated and purified from the herbs of Equisetum hyemale L., induces HepG2 apoptosis in a ROS-mediated mitochondria-dependent manner that correlate with the inactivation of the PI3K/Akt pathway, exerts an anti-inflammatory effect through suppression of LPS-induced JNK and NF-κB signaling pathways and diminished production of proinflammatory cytokines and mediators, and is a Met inhibitor with a potential utility in cancer therapeutics, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation. 4. Herbacetin
Herbacetin 细胞实验
Cell Line
Concentration
Treated Time
Description
References
cardiomyocytes
50 μmol
48 hours
Evaluate the inhibitory effect of HBT on phenylephrine-induced cardiomyocyte hypertrophy, results showed HBT significantly suppressed cardiomyocyte hypertrophy
Adv Sci (Weinh). 2022 Jan;9(2):e2101485
HepG2 cells
1–250 µM
72 hours
Evaluated cytotoxicity, results showed Herbacetin had minimal impact on HepG2 cell growth with an IC50 value of 218.90 µM ± 4.53
Pharmaceuticals (Basel). 2025 Jan 10;18(1):76
BASE-2B cells
5, 10, 20 μm
24 hours
Herbacetin reduced LPS-induced inflammation and ROS generation in BESA-2B cells, inhibited cell apoptosis, and promoted cell proliferation.
J Asthma Allergy. 2024 Jul 22;17:703-716
Herbacetin 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6J mice
ISO-induced cardiac hypertrophy model
Intraperitoneal injection
10 mg/kg
Once daily for 21 days
Evaluate the inhibitory effect of HBT on cardiac hypertrophy, results showed HBT significantly improved cardiac function and reduced cardiac hypertrophy
Adv Sci (Weinh). 2022 Jan;9(2):e2101485
C57BL/6J(Min/+) mice
APC-driven colon cancer model
Intraperitoneal injection
0.4 or 2 mg/kg body weight
3 times a week for 8 weeks
Herbacetin significantly suppressed the number and size of polyps and reduced putrescine and spermidine levels.
Cancer Res. 2016 Mar 1;76(5):1146-1157
Sprague Dawley rats
Thioacetamide (TAA)-induced hepatic encephalopathy (HE) model
Oral
20 and 40 mg/kg
Once daily for 30 days
To evaluate the neuroprotective and cognitive enhancing effects of Herbacetin against TAA-induced hepatic encephalopathy (HE) in rats. Results showed that Herbacetin improved locomotor and cognitive deficits, reduced serum hepatotoxicity indices and ammonia levels, decreased brain oxidative stress and inflammation, and upregulated AMPK and SIRT1 signaling pathways.
Sci Rep. 2024 May 18;14(1):11396
C57BL/6J mice
OVA-induced asthma model
Intraperitoneal injection
25, 50, 100 mg/kg
Once every 7 days for 14 consecutive days
Herbacetin alleviated lung inflammation in OVA-induced asthmatic mice, improving the number of inflammatory cells and secretion of inflammatory factors in bronchoalveolar lavage fluid.
J Asthma Allergy. 2024 Jul 22;17:703-716
Hairless SKH:HR-1-hrBr (SKH-1) mice
DMBA/TPA two-stage skin carcinogenesis mouse model
Topical application
100 or 500 nmol
Twice weekly for 20 weeks
Herbacetin decreased the number and volume of skin papillomas
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