HLY78
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货号：A1177124
HLY78是一种 Wnt/β-catenin 信号通路激活剂，靶向 Axin 的 DIX 结构域，促进 Axin-LRP6 关联及 LRP6 磷酸化，增强 Wnt 信号转导。它在研究蛛网膜下腔出血 (SAH) 和相关疾病中的潜在应用具有重要价值。
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type HazMat fee for 500 gram (Estimated) Excepted Quantity USD 0.00 Limited Quantity USD 15-60 Inaccessible (Haz class 6.1), Domestic USD 80+ Inaccessible (Haz class 6.1), International USD 150+ Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+ Accessible (Haz class 3, 4, 5 or 8), International USD 200+
HLY78 化学结构
HLY78 3D分子结构
规格
价格
会员价
库存
数量
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HLY78 纯度/质量文件 产品仅供科研
货号：A1177124
标准纯度：
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产品说明书
全球学术期刊中引用的产品
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HLY78 质控信息
HLY78 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HCT-116 cells
10 mM
48 h
To evaluate the effect of HLY78 on GANT61-treated HCT-116 cells, HLY78 improved relative cell viability and reduced apoptosis
Oncol Rep. 2022 Oct;48(4):182.
HT-29 cells
10 mM
48 h
To evaluate the effect of HLY78 on GANT61-treated HT-29 cells, HLY78 improved relative cell viability and reduced apoptosis
Oncol Rep. 2022 Oct;48(4):182.
769-P cells
10 µM
48 h
By activating the Wnt/β-catenin pathway, it restored the malignant proliferation and metastasis capacity of ccRCC cells after RHBDL2 knockdown.
Sci Rep. 2024 Nov 7;14(1):27053.
786-O cells
10 µM
48 h
By activating the Wnt/β-catenin pathway, it restored the malignant proliferation and metastasis capacity of ccRCC cells after RHBDL2 knockdown.
Sci Rep. 2024 Nov 7;14(1):27053.
airway fibroblasts
10 µM
24 h
HLY78 significantly reduced the inhibitory and pro-apoptotic effects of HSG overexpression on airway fibroblasts
Mol Med Rep. 2019 Sep;20(3):2754-2762.
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HLY78 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague-Dawley rats
Subarachnoid hemorrhage model
Intranasal injection
0.6 mg/kg
Single administration
HLY78 attenuates neuronal apoptosis and improves neurological deficits through the LRP6/GSK3β/β-catenin signaling pathway after SAH in rats.
Neurosci Bull. 2020 Oct;36(10):1171-1181
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HLY78 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.74mL
0.75mL
0.37mL
18.70mL
3.74mL
1.87mL
37.41mL
7.48mL
3.74mL
HLY78 技术信息
搜索
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