Gardenoside, a natural product isolated and purified from the fruits of Gardenia jasminoides Ellis, has anti-inflammatory, analgesic activities.
Gardenoside/羟异栀子苷 细胞实验
Cell Line
Concentration
Treated Time
Description
References
HL-60
5 μM
48 hours
Evaluate the inhibitory effect of Gardenoside on AML cell proliferation
Genes Dis. 2023 Jan 25;11(1):397-412
U-937
5 μM
48 hours
Evaluate the inhibitory effect of Gardenoside on AML cell proliferation
Genes Dis. 2023 Jan 25;11(1):397-412
THP-1
5 μM
48 hours
Evaluate the inhibitory effect of Gardenoside on AML cell proliferation
Genes Dis. 2023 Jan 25;11(1):397-412
HepG2 cells
10 µM, 20 µM
24 hours
To study the effect of Gardenoside on FFAs-induced steatosis in HepG2 cells, results showed that Gardenoside significantly reduced intracellular lipid accumulation.
Int J Mol Sci. 2015 Nov 20;16(11):27749-56
HepG2 cells
10 µM, 20 µM
24 hours
To evaluate the effect of Gardenoside on HepG2 cell viability, results showed that 10 and 20 µM Gardenoside had no significant toxic effect on cell viability.
Int J Mol Sci. 2015 Nov 20;16(11):27749-56
BRL-3A rat liver cells
100–500 µg/mL
24 hours
Evaluate the effect of Gardenoside on cell viability. Results showed that Gardenoside inhibited cell growth in a dose-dependent manner at concentrations of 100–500 µg/mL.
Molecules. 2019 Oct 30;24(21):3920
Gardenoside/羟异栀子苷 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
NOD/SCID mice
AML patient-derived xenograft model
Intraperitoneal injection
15 mg/kg
Three times a week for three weeks
Evaluate the anti-tumor effect of Gardenoside combined with rapamycin in AML mouse model
Genes Dis. 2023 Jan 25;11(1):397-412
Kunming mice
Montmorillonite-induced constipation model
Intragastric administration
50 mg/kg
Once daily for 9 days
To study the relieving effect of Gardenoside on constipated mice. Results showed that Gardenoside increased the propelling rate of activated carbon in the small intestines of mice, accelerated the discharge of the first black stool, regulated the levels of gastrointestinal hormones in serum, and improved oxidative stress and tissue damage.
RSC Adv. 2020 Mar 11;10(17):10368-10381
BABL/C mice
S. aureus-induced mastitis model
10, 20, 40 mg/kg
Sacrificed after 24 hours
GAD alleviated inflammation and ferroptosis by activating the Nrf2/SLC7A11/GPX4 signaling pathway, improving mammary histopathological damage
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