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全部(90) Modulator(1) Agonist(1) Antagonist(10) Inhibitor(1)
A 438079 is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).
BAY-1797是一种高效、口服活性的选择性 P2X4 拮抗剂,对人 P2X4 的 IC50 为 211 nM。BAY-1797 在其他 P2X 离子通道上没有或表现出极弱的活性,具有抗伤害和抗炎作用。
AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth .
A 438079 HCl is a competitive P2X7 receptor antagonist (pIC50 = 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line).
GW791343 2HCl is a P2X7 allosteric modulator exhibiting species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2).
A-804598 是一个 CNS 渗透,竞争性和选择性的 P2X7 受体拮抗剂,作用于小鼠,大鼠和人的 P2X7 受体,IC50s 分别是 9 nM, 10 nM 和 11 nM。
AF-353 is a potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).
A-317491 is a potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.
Gefapixant 是一种口服活性的 P2X3 受体(P2X3R)拮抗剂,对重组人 hP2X3 和 hP2X2/3 的 IC50 值分别约为 30 nM 和 100-250 nM。Gefapixant 可用于慢性咳嗽和膝骨关节炎的研究。
A-839977 is a selective P2X7 antagonist and blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20, 42 and 150 nM respectively).
BX430 is selective P2X4 allosteric antagonist with IC50 of 0.54 μM.
RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist.
JNJ 47965567 is a potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively).
CTP Disodium Dihydrate is a P2X4 purinergic receptor agonist.
Oxatomide is a first-generation antihistamine of the diphenylmethylpiperazine (benzhydrylpiperazine) class.
KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II (CaMK-II) with IC50 of 0.9 μM, KN-62 also displays noncompetitive antagonism at P2X7 receptors in HEK293 cells, with an IC50 value of approximately 15 nM..
Gardenoside, a natural product isolated and purified from the fruits of Gardenia jasminoides Ellis, has anti-inflammatory, analgesic activities.
Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase.
Tags: P2X受体 | P2X Receptor | 神经信号通路 | Neuronal Signaling | 膜转运蛋白 | Membrane Transporter/Ion Channel | P2X受体 相关产品
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