Garcinone C, a natural product isolated and purified from the fruits of Garcinia mangostana, is the most potent inhibitor of AChE, the most active compound against both of pathogenic (MIC =100 μg/mL) and non-pathogenic leptospira (MIC = 200 μg/mL), and exhibits either significant or moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro.
Garcinone C/伽升沃 C 细胞实验
Cell Line
Concentration
Treated Time
Description
References
MDA-MB-231
5 μM
24 hours
Restored TBK1 phosphorylation in PD-L1 KO cells
EMBO Rep. 2025 Feb;26(3):635-655
BMDM cells
0, 0.2, 1, 5 μmol/L
5 days
To investigate the inhibitory effect of Garcinone C on RANKL-induced osteoclast differentiation. Results showed that Garcinone C significantly inhibited osteoclast differentiation and bone resorption function.
Heliyon. 2024 Feb 1;10(3):e25601
RAW264.7 cells
0, 0.2, 1, 5 μmol/L
5 days
To investigate the inhibitory effect of Garcinone C on RANKL-induced osteoclast differentiation. Results showed that Garcinone C dose-dependently reduced the osteoclast area and significantly inhibited the formation of multinucleated osteoclasts.
Heliyon. 2024 Feb 1;10(3):e25601
MDA-MB-231
5 μM
5 days
Restored IL-6 and GM-CSF expression in PD-L1 KO cells
EMBO Rep. 2025 Feb;26(3):635-655
MDA-MB-231
5 μM
5 days
Restored cGAMP production in PD-L1 KO cells
EMBO Rep. 2025 Feb;26(3):635-655
22Rv1 cells
IC50 value of 22.62 μM
48 hours
Evaluated the cytotoxicity of Garcinone C on prostate cancer cells 22Rv1, showing an IC50 value of 22.62 μM.
Nat Prod Res. 2021 Dec;35(23):5429-5433
MDA-MB-231 cells
IC50 value of 22.62 μM
48 hours
Evaluated the cytotoxicity of Garcinone C on breast cancer cells MDA-MB-231, showing an IC50 value of 22.62 μM.
Nat Prod Res. 2021 Dec;35(23):5429-5433
HepG2 cells
6, 8, 10 μg/mL
48 hours
To evaluate the inhibitory effect of Garcinone C on the growth of HepG2 cells, results showed IC50 of 6.23 μg/mL (extract) and 5.78 μg/mL (nanoemulsion).
Int J Mol Sci. 2023 Feb 15;24(4):3934
Garcinone C/伽升沃 C 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
OVX-induced osteoporosis model
Intraperitoneal injection
5 mg/kg and 25 mg/kg
Every 2 days for 8 weeks
To investigate the therapeutic effect of Garcinone C on OVX-induced osteoporosis. Results showed that Garcinone C significantly increased bone mineral density, reduced bone loss, and inhibited the expression of osteoclast-related proteins.
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