Garcinone C

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Chemical Structure| 76996-27-5 同义名 : -
CAS号 : 76996-27-5
货号 : A589339
分子式 : C23H26O7
纯度 : 99%+
分子量 : 414.45
MDL号 : MFCD11111285
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(253.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Garcinone C, a natural product isolated and purified from the fruits of Garcinia mangostana, is the most potent inhibitor of AChE, the most active compound against both of pathogenic (MIC =100 μg/mL) and non-pathogenic leptospira (MIC = 200 μg/mL), and exhibits either significant or moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.41mL

0.48mL

0.24mL

12.06mL

2.41mL

1.21mL

24.13mL

4.83mL

2.41mL
参考文献

[1]Khaw KY, Choi SB, et al. Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies. Phytomedicine. 2014 Sep 25;21(11):1303-9.

[2]Seesom W, Jaratrungtawee A, et al. Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G. BMC Complement Altern Med. 2013 Jul 19;13:182. doi: 10.1186/1472-6882-13-182.