To investigate the effect of Fostamatinib on macrophage polarization. Results showed that Fostamatinib prevented IL4-induced expression of immunosuppressive genes and downregulated the expression of these genes in macrophages cocultured with KPC1245 tumor cells.
Orthotopic pancreatic ductal adenocarcinoma (PDAC) model
Intraperitoneal injection
50 mg/kg
Five times per week, continuous treatment
To evaluate the effect of Fostamatinib alone or in combination with gemcitabine on PDAC growth and metastasis. Results showed that Fostamatinib significantly reduced tumor growth and metastasis and remodeled the tumor immune microenvironment, enhancing CD8+ T cell responses.
Cancer Res. 2023 Aug 15;83(16):2675-2689.
NOD.SCID mice
Xenogeneic model of EBV+ B-cell lymphoma
Oral
fostamatinib-containing chow
Continuous administration
Syk inhibition did not significantly affect solid tumor growth but resulted in tumor growth in adjacent inguinal lymph nodes
Am J Transplant. 2013 Apr;13(4):883-890.
Mice
Wild-type neonatal mice
Oral
40 mg/kg body weight
Every 6 hours for 8 days
To evaluate the effect of SYK inhibitor fostamatinib on the lymphatic system, results showed no detectable entry of blood into the thoracic duct
J Clin Invest. 2014 Jan;124(1):273-84
C57BL/6J mice
Ischemia/reperfusion (I/R)-induced acute lung injury model
Oral
3 g/kg
Once daily for 10 days
To evaluate the effect of Fostamatinib (R788) on MUC1 levels in a model of acute lung injury. Results showed that Fostamatinib significantly reduced MUC1 abundance in lung epithelial cells.
Cell Rep Med. 2020 Oct 29;1(8):100137.
Apoe-/- mice
High cholesterol diet-induced atherosclerosis model
Dietary administration
0.3% (w/w)
Continuous for 8 or 20 weeks
Evaluate the effect of Fostamatinib on early and late-stage atherosclerosis. Results showed Fostamatinib significantly reduced plaque size and macrophage accumulation in early lesions but had limited effect in late-stage lesions.
Basic Res Cardiol. 2016 Mar;111(2):20.
NOD/SCID gamma mice
Subcutaneous xenograft model
Intraperitoneal injection
40 mg/kg and 80 mg/kg
Daily administration for 33 days
To evaluate the inhibitory effect of Fostamatinib on xenograft tumor growth.
Cell Mol Gastroenterol Hepatol. 2018 Jan 31;5(4):569-590
搜索
