Fosinopril sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor and has the greatest lipophilicity[3]. Once daily administration of fosinopril at 20 and 40 mg was safe and well tolerated, provided a sustained beneficial hemodynamic effect, improved left ventricular performance, and reduced symptoms of dyspnea, resulting in a reduced need for supplemental diuretic therapy[4]. Further, Fosinopril ameliorated diabetic renal injuries by inhibiting oxidative stress[5].
Fosinopril sodium/福辛普利钠 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
ICR mice
Acute myocardial infarction model
Intragastric administration
10 mg/kg
Once daily for 7 days
To evaluate the protective effect of Fosinopril on cardiac function in mice with acute myocardial infarction, the results showed that Fosinopril significantly improved cardiac function parameters (LVEDd, LVEDs, EF, and FS)
Chin Med. 2023 Mar 17;18(1):29
Spontaneously hypertensive rats (SHR)
Spontaneously hypertensive rat model
Oral
2.5 mg/kg
Once daily for 12 weeks
To evaluate the antihypertensive effect of Fosinopril sodium in SHR, results showed significant reductions in systolic, diastolic, and mean blood pressures after single and long-term administration.
Front Pharmacol. 2019 Apr 30;10:403
Sprague Dawley (SD) rats
Chronic heart failure (CHF) rat model
Oral
4.67 mg/kg
Once daily for 28 and 60 days
To evaluate the effect of Fosinopril sodium on heart function and renal fibrosis in CHF rats. Results showed that Fosinopril sodium improved heart function parameters (e.g., EF and FS) and reduced the expression of renal fibrosis-related indicators (e.g., CTGF and α-SMA).
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