Fosinopril sodium
产品说明书
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同义名 : | SQ28555; Fosinopril(sodium salt); Tensocardil; Tenso Stop; Fosinil; Dynacil; Staril; Monopril |
| CAS号 : | 88889-14-9 | |
| 货号 : | A213166 | |
| 分子式 : | C30H45NNaO7P | |
| 纯度 : | 98% | |
| 分子量 : | 585.64 | |
| MDL号 : | MFCD00865785 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 1 mg/mL(1.71 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 25 mg/mL(42.69 mM)，配合低频超声，并水浴加热至45℃助溶 无水乙醇: 15 mg/mL(25.61 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
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| 靶点 |
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| 描述 | Fosinopril sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor and has the greatest lipophilicity[3]. Once daily administration of fosinopril at 20 and 40 mg was safe and well tolerated, provided a sustained beneficial hemodynamic effect, improved left ventricular performance, and reduced symptoms of dyspnea, resulting in a reduced need for supplemental diuretic therapy[4]. Further, Fosinopril ameliorated diabetic renal injuries by inhibiting oxidative stress[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.71mL 0.34mL 0.17mL |
8.54mL 1.71mL 0.85mL |
17.08mL 3.42mL 1.71mL |
| 参考文献 |
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