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/ Flurbiprofen/氟比洛芬

Flurbiprofen/氟比洛芬 {[allProObj[0].p_purity_real_show]}

货号：A481951 同义名： dl-Flurbiprofen; Ansaid

Flurbiprofen是一种非甾体抗炎药（NSAIA），具有退热和镇痛活性。 (±)-Flurbiprofen在前列腺癌、家族性腺瘤性息肉病和脑癌模型中抑制肿瘤生长，维持在诱导分化的条件下生长的 hESC 细胞的自我更新和多能性。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Flurbiprofen/氟比洛芬 化学结构 CAS号：5104-49-4
Flurbiprofen/氟比洛芬 化学结构
CAS号：5104-49-4
Flurbiprofen/氟比洛芬 3D分子结构
CAS号：5104-49-4
Flurbiprofen/氟比洛芬 化学结构 CAS号：5104-49-4
Flurbiprofen/氟比洛芬 3D分子结构 CAS号：5104-49-4
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Flurbiprofen/氟比洛芬 纯度/质量文件 产品仅供科研

货号：A481951 标准纯度： {[allProObj[0].p_purity_real_show]}
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Flurbiprofen/氟比洛芬 生物活性

描述 Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.

Flurbiprofen/氟比洛芬 细胞实验

Cell Line
Concentration Treated Time Description References
Rabbit skin 150 mg 24 hours Evaluate the penetration enhancement effect of GER-C14 on Flurbiprofen, results showed GER-C14 had the best penetration promotion effect. Asian J Pharm Sci. 2022 Jan;17(1):139-152
HCA-7 cells 11.7 µM 16 hours R-flurbiprofen inhibited PGE2 release in HCA-7 cells with an IC50 of 11.7 µM. Int J Mol Sci. 2016 Dec 30;18(1):68
A-549 cells 5.6 µM 16 hours R-flurbiprofen inhibited PGE2 release in A-549 cells with an IC50 of 5.6 µM. Int J Mol Sci. 2016 Dec 30;18(1):68
HeLa cells 5.1 µM 16 hours R-flurbiprofen inhibited PGE2 release in HeLa cells with an IC50 of 5.1 µM. Int J Mol Sci. 2016 Dec 30;18(1):68
B103 murine neuronal cell line 400 μM or 1 mM 6 and 9 hours post-infection Flurbiprofen in combination with the caspase inhibitor Z-VAD-fmk drastically reduced HSV-1-induced Aβ42 oligomer production. Transl Psychiatry. 2023 Mar 10;13(1):86
Caco-2 cells 0, 0.5, 2.5, 5, 25, 50 µg/mL (corresponds to 0, 2, 10.2, 20.5, 102.3, 204.7 µM) 24 h or 48 h To investigate the effect of flurbiprofen on ACE2 mRNA and protein expression. Results showed flurbiprofen did not alter ACE2 mRNA expression but slightly increased ACE2 protein expression. Int J Mol Sci. 2022 Jan 19;23(3):1049
C6 glial cells 200 µM 4 hours To assess the effect of FP-loaded dendrimeric delivery systems on γ-secretase enzyme activity. Results showed that FP and FP-dendrimer complexes significantly reduced γ-secretase activity. Int J Mol Sci. 2018 Oct 18;19(10):3224
bEnd.3 cells 25 to 400 µM 24 and 48 hours To evaluate the cytotoxicity and biocompatibility of FP-loaded dendrimeric delivery systems. Results showed cell viability exceeding 70% at concentrations up to 400 µM, indicating these delivery systems were non-toxic to these cells. Int J Mol Sci. 2018 Oct 18;19(10):3224

Flurbiprofen/氟比洛芬 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Japanese white rabbits Transdermal delivery model Transdermal administration 208.8 mg Single dose, 48 hours duration Evaluate the pharmacokinetic impact of GER-C14 on Flurbiprofen, results showed GER-C14 significantly increased Cmax and AUC0-48. Asian J Pharm Sci. 2022 Jan;17(1):139-152
Sprague-Dawley rats Collagenase II-induced knee osteoarthritis model Intra-articular injection 0.5 mg/time Every 72 hours for 7 times To evaluate the therapeutic effects of flurbiprofen thermogel in a knee osteoarthritis model, showing significant reduction in pain and inflammatory response. Drug Deliv. 2020 Dec;27(1):1034-1043
Japanese white rabbits Transdermal delivery model Transdermal administration 208.8 mg FP Single dose, 48 hours duration To evaluate the transdermal enhancement effect of GER-C14 in vivo. Results showed that the GER-C14 group had the highest AUC0–48, indicating the strongest transdermal enhancement effect. Asian J Pharm Sci. 2022 Jan;17(1):139-152

Flurbiprofen/氟比洛芬 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02191358 - Completed - United States, California ... 展开 >> Dr. Michael Dao Garden Grove, California, United States, 92844 United States, Colorado Kaiser Permanente Colorado Denver, Colorado, United States, 80011 United States, Kentucky Gill Heart Institute Lexington, Kentucky, United States, 40508 United States, Maryland IRC Clinics Towson, Maryland, United States, 21204 United States, Massachusetts Internal Medicine & Cardiology Associates Fall River, Massachusetts, United States, 02720 Prima CARE Fall River, Massachusetts, United States, 02720 United States, Virginia Carilion Clinic Christiansburg, Virginia, United States, 24073 收起 <<
NCT03520907 Postoperative Pain ... 展开 >> Inguinal Hernia Unilateral Children, Only 收起 << Not Applicable Recruiting April 2019 Japan ... 展开 >> Ibaraki Children's Hospital Recruiting Mito, Ibaraki, Japan, 311-4145 Contact: Kazuhiko Okuyama, MD    81-29-254-1151    okuokukk@gmail.com    Principal Investigator: Yuki Takeda, MD          Sub-Investigator: Iwao Sukegawa, MD 收起 <<
NCT02784041 Osteoarthritis,Knee Not Applicable Unknown December 2018 China ... 展开 >> Peking Union Medical College Hospital Beijing, China, 100730 收起 <<

Flurbiprofen/氟比洛芬 参考文献

[1]Mishra V, Verma R, Raghubir R. Neuroprotective effect of flurbiprofen in focal cerebral ischemia: the possible role of ASIC1a. Neuropharmacology. 2010 Dec;59(7-8):582-8.

[2]King JG Jr, Khalili K. Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen. Oncogene. 2001 Oct 18;20(47):6864-70.

Flurbiprofen/氟比洛芬 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.09mL

0.82mL

0.41mL

20.47mL

4.09mL

2.05mL

40.94mL

8.19mL

4.09mL

Flurbiprofen/氟比洛芬 技术信息

CAS号5104-49-4
分子式C15H13FO2
分子量 244.26
SMILES Code O=C(O)C(C)C1=CC=C(C2=CC=CC=C2)C(F)=C1
MDL No. MFCD00079303
别名 dl-Flurbiprofen; Ansaid; Flurbiprofen, Ansaid, Froben, Cebutid, Antadys; (±)-Flurbiprofen
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, sealed in dry, room temperature
溶解方案

DMSO: 105 mg/mL(429.87 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三

Tags: Flurbiprofen | dl-Flurbiprofen;Ansaid;Flurbiprofen, Ansaid, Froben, Cebutid, Antadys;(±)-Flurbiprofen | Anti-inflammation | Cyclooxygenase (COX) | Cyclooxygenase (COX) Inhibitor | PG Synthase | AmBeed-信号通路专用抑制剂 | Flurbiprofen/氟比洛芬 纯度/质量文件 | Flurbiprofen/氟比洛芬 生物活性 | Flurbiprofen/氟比洛芬 临床数据 | Flurbiprofen/氟比洛芬 参考文献 | Flurbiprofen/氟比洛芬 实验方案 | Flurbiprofen/氟比洛芬 技术信息

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