FT011, recognized as an anti-fibrotic compound, diminishes the mRNA levels of collagen types I and III and curtails the synthesis of collagen[1].
FT011 细胞实验
Cell Line
Concentration
Treated Time
Description
References
Rat cardiac fibroblasts (RCF)
10 μM
12 hours
To assess the inhibitory effect of FT011 on TGF-β1-induced cardiac fibroblast fibrosis. Results showed that FT011 significantly reduced the expression of α-SMA, collagen I, and collagen III.
Mater Today Bio. 2025 May 14;32:101854
Müller cells
10, 30, 100 μM
72 hours
To evaluate the effects of FT011M on hyperglycaemia-induced injury in Müller cells. FT011M reduced the hyperglycaemic-induced increase in MCP-1, sICAM-1, CCL20, GRO/CINC-1, VEGF, and IL-6 protein levels.
PLoS One. 2015 Jul 29;10(7):e0134392
FT011 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Ren-2 rats
Diabetic retinopathy model
Intravitreal injection
50 μM
8-week and 32-week studies, with injections at 2 days and 4 weeks (8-week study) and at 16, 20, 24, and 28 weeks (32-week study)
To evaluate the protective effects of FT011 on diabetic retinopathy. FT011 reduced retinal leukostasis, microglial density, ICAM-1 mRNA levels, Müller cell gliosis, VEGF immunolabeling, and the number of acellular capillaries.
PLoS One. 2015 Jul 29;10(7):e0134392
FT011 动物研究
Animal study
When administered at a dose of 100 mg/kg twice daily orally for four weeks, FT011 enhances cardiac function and myocardial structure in rats with myocardial infarction[1].
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