Eribulin mesylate, at concentrations ranging from 1 to 100 nM over 72 hours, inhibits cell proliferation with IC50 values of 22.8 nM for LM8 cells and 21.5 nM for Dunn cells[1]. Eribulin mesylate (1-100 nM; 72 h) inhibits cell proliferation with IC50 values of 22.8 nM for LM8 cells and 21.5 nM for Dunn cells[1]. Eribulin mesylate (10-50 nM; 12-72 h) induces G2/M arrest in LM8 cells within 12 hours at a concentration of 50 nM. However, this effect is not observed with a longer treatment duration of 72 hours at 10 nM[1]. Eribulin mesylate, at concentrations from 1 to 50 nM over 12 hours, does not induce senescence in LM8 cells[1]. Eribulin mesylate (1-10 nM; 16 h) induces morphological changes and suppresses cell migration in LM8 cells[1].
体内研究
Eribulin mesylate (1 mg/kg; i.v. once a week for 2 weeks) reduces primary tumor growth and lung metastasis in a mouse model of osteosarcoma[1].
Eribulin mesylate (1 mg/kg; once i.v.) suppresses the appearance of circulating tumor cells (CTC) during the low-concentration phase[1].
体外研究
Eribulin mesylate, at concentrations ranging from 1 to 100 nM over 72 hours, inhibits cell proliferation with IC50 values of 22.8 nM for LM8 cells and 21.5 nM for Dunn cells[1].
Eribulin mesylate (1-100 nM; 72 h) inhibits cell proliferation with IC50 values of 22.8 nM for LM8 cells and 21.5 nM for Dunn cells[1].
Eribulin mesylate (10-50 nM; 12-72 h) induces G2/M arrest in LM8 cells within 12 hours at a concentration of 50 nM. However, this effect is not observed with a longer treatment duration of 72 hours at 10 nM[1].
Eribulin mesylate, at concentrations from 1 to 50 nM over 12 hours, does not induce senescence in LM8 cells[1].
Eribulin mesylate (1-10 nM; 16 h) induces morphological changes and suppresses cell migration in LM8 cells[1].
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