Eribulin Mesylate
产品说明书
 |
同义名 : | Eribulin甲磺酸盐 ;B1939 mesylate; E7389 mesylate; ER-086526 mesylate |
| CAS号 : | 441045-17-6 | |
| 货号 : | A306236 | |
| 分子式 : | C41H63NO14S | |
| 纯度 : | 98% | |
| 分子量 : | 826.0 | |
| MDL号 : | MFCD22572760 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(127.12 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 无水乙醇: 100 mg/mL(121.07 mM)，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Eribulin mesylate, at concentrations ranging from 1 to 100 nM over 72 hours, inhibits cell proliferation with IC50 values of 22.8 nM for LM8 cells and 21.5 nM for Dunn cells[1]. Eribulin mesylate (1-100 nM; 72 h) inhibits cell proliferation with IC50 values of 22.8 nM for LM8 cells and 21.5 nM for Dunn cells[1]. Eribulin mesylate (10-50 nM; 12-72 h) induces G2/M arrest in LM8 cells within 12 hours at a concentration of 50 nM. However, this effect is not observed with a longer treatment duration of 72 hours at 10 nM[1]. Eribulin mesylate, at concentrations from 1 to 50 nM over 12 hours, does not induce senescence in LM8 cells[1]. Eribulin mesylate (1-10 nM; 16 h) induces morphological changes and suppresses cell migration in LM8 cells[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.21mL 0.24mL 0.12mL |
6.05mL 1.21mL 0.61mL |
12.11mL 2.42mL 1.21mL |
| 参考文献 |
|---|