Dimetridazole is a nitroimidazole class drug that combats protozoan infections. Dimetridazole achieved higher MIC100 activity than metronidazole against the resistant isolate. The use of dimetridazole as a promising drug-like scaffold for novel therapeutic alternatives against T. vaginalis resistant infections[3]. Dimetridazole was formulated for drinking water medication and as a prolonged-release tablet. To suppress a Trichomonas gallinae infection successfully, medicated drinking water containing dimetridazole (400 mg/L) had to be administered for at least 3 days. After intravenous administration of 20 mg dimetridazole, the drug plasma concentration-time profile fitted a one-compartment open model with a mean half-life of 3.9 h. The absolute bioavailability of the tablet in fasted pigeons was 83.8%. The bioavailability of the tablet administered with food was reduced by 20%[4]. Dimetridazole, either when used alone or in conjunction with oxytetracycline, had a marked effect on ruminal function. Within 6 h of dosing, the ruminal pH fell to below 5, but then returned to pretreatment values over the next 24 - 48h[5]. Dimetridazole at a concentration of 1.0 g/l in drinking water caused mortality in both ducklings and goslings. When given to goslings at a concentration of 0.5 g/l, the drug caused growth depression and nervous signs characterized by excess activity, abnormal head attitudes, and ataxia[6].
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