DPCPX significantly augmented the C-fiber-evoked spinal local field potential (C-LFP) and increased the amplitude of A-LFP in nerve-injured rats, indicating that A1R activation exerts tonic inhibition on spinal nociceptive transmission.
Br J Anaesth. 2024 Apr;132(4):746-757
PFC pyramidal neurons
0.3 μM
Blocked the inhibitory effect of 40 Hz light flicker on excitatory transmission, increased sEPSC frequency and amplitude
Mol Psychiatry. 2024 Nov;29(11):3381-3394
rat mesenteric vascular bed
1 μmol/L
DPCPX significantly inhibited norepinephrine-induced mesenteric vasoconstriction, indicating that A1 receptor signaling plays an important role in α1-adrenoceptor-mediated vasoconstriction.
Hypertension. 2020 Oct;76(4):1308-1318
DPCPX 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Sprague-Dawley rats
Tibial-spared nerve injury (SNI-t) model
Spinal topical application
50 μM
Single administration, 30 minutes exposure
DPCPX significantly augmented the C-fiber-evoked spinal local field potential (C-LFP) and increased the amplitude of A-LFP in nerve-injured rats by blocking A1R activation, indicating that A1R activation exerts tonic inhibition on spinal nociceptive transmission. Additionally, DPCPX blocked the inhibition of C-LFP by spinal cord stimulation (SCS).
Br J Anaesth. 2024 Apr;132(4):746-757
Sprague-Dawley rats
Transient middle cerebral artery occlusion (MCAO) model
Intraperitoneal (i.p.) administration
1.25 mg/kg
Once daily for 6 consecutive days
To evaluate the effect of DPCPX on neuroinflammation after cerebral ischemia, results showed that DPCPX treatment group had improved brain lesion volume and neurological scores.
Theranostics. 2021 Jan 1;11(1):410-425
Female 16p11.2 deletion mice
16p11.2 deletion mouse model
Intragastric
4 mg/kg
Once daily for 14 days
Blocked the ameliorative effect of 40 Hz light flicker on social novelty deficits, increased anxiety levels
Mol Psychiatry. 2024 Nov;29(11):3381-3394
Mice
Wild type mice
Epidural application or intracortical injection
0.7–1 mM (epidural application) or 30 μM (intracortical injection)
DPCPX induced spontaneous CSDs but only small-DC shifts along with suppression of EEG spikes during photic stimulation, suggesting that the inhibition co-activated with sensory stimulation could limit CSD ignition when K+ uptake was not sufficiently suppressed as with ouabain.
J Headache Pain. 2022 Aug 19;23(1):107
Sprague–Dawley rats
Parkinson's disease model
Intraperitoneal injection
3 mg/kg
Once daily for 7 consecutive days
To investigate the inhibitory effect of DPCPX on CPA-induced α-synuclein expression/aggregation and neurodegeneration. Results showed that DPCPX and 1-aminoindan attenuated CPA-induced α-synuclein expression/aggregation and neurodegeneration in the substantia nigra and hippocampus.
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