DETA NONOate是一种外源性一氧化氮 (NO) 供体，显示出常规 NO 缓释效果并具有长效作用。
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DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor, characterized by a slow and sustained release of physiologically relevant levels of NO, exhibiting long-acting effects [1][2].
体内研究
DETA NONOate (15-150 μg/rat, iC.v., once) demonstrates nociceptive activity in the rat formalin model [2].
DETA NONOate (1 µM) attenuates ischemia- or reperfusion-induced damage to cardiac mitochondria and inhibits apoptotic cell death [4].
体外研究
DETA NONOate (100 μM; 16 h) promotes growth in the R morphotype of Mycobacterium abscessus complex (MABC) by decreasing the expression of glycopeptidolipids (GPL) in Mycobacterium abscessus subspecies abscessus (Mab) [3].
DETA NONOate 细胞实验
Cell Line
Concentration
Treated Time
Description
References
β-TC6 cells
2.5 mM
24 h
To assess the effect of TAB1 overexpression on NO-induced cell death, results showed that TAB1 overexpression increased NO-induced cell death rate.
Int J Biol Sci. 2006 Nov 25;3(2):71-6
β-TC6 cells
2.5 mM
30 min
To investigate the role of TAB1 in NO-induced p38 phosphorylation, results showed that TAB1 overexpression enhanced p38 phosphorylation.
Int J Biol Sci. 2006 Nov 25;3(2):71-6
Primary human bronchial epithelial (HBE) cells
50 µM
24 h
To investigate the ability of HBE cells to convert NO to nitrite/nitrate and the effect of oxygen reactions on nitrite/nitrate formation. Results showed that HBE cells have the capacity to oxidize NO to nitrite/nitrate even under low oxygen conditions.
Free Radic Biol Med. 2013 Aug;61:428-37
A549 cells
50 µM
24 h
To investigate the ability of A549 cells to convert NO to nitrite/nitrate and the effect of oxygen reactions on nitrite/nitrate formation. Results showed that A549 cells have the capacity to oxidize NO to nitrite/nitrate even under low oxygen conditions.
Free Radic Biol Med. 2013 Aug;61:428-37
human vascular smooth muscle cells (hVSMCs)
10 μM
16 h
To study the effects of DETA-NONOate on PDE5 and NOX-1 expression. Results showed that DETA-NONOate completely blocked superoxide release and PDE5 protein expression and activity.
Br J Pharmacol. 2008 Nov;155(6):847-56
porcine coronary arteries
10 µM
24 h
To investigate the effect of DETA NONOate on the relaxant response of coronary arteries, results showed attenuated relaxation response to DETA NONOate after 24-hour incubation.
Br J Pharmacol. 2008 Feb;153(3):497-507
HT-29 cells
50 nM
72 h
To investigate the effect of NO on the invasiveness of HT-29 cells, results showed that 50 nM DETA NONOate increased the invasiveness of HT-29 cells by approximately 40%
Br J Cancer. 2002 Apr 22;86(8):1310-5
DETA NONOate 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Mice
Pilocarpine-induced temporal lobe epilepsy model
Intraperitoneal injection
1 mg/kg
Once daily for 2 months
Chronic treatment with DETA/NONOate prevented the development of epileptogenesis by blocking aberrant excitatory afferent circuit formation of DGCs, but had no acute antiseizure effects.
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