DETA NONOate

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Chemical Structure| 146724-94-9 同义名 : Diethylamine NONOate; NOC-18; Diethylenetriamine NONOate
CAS号 : 146724-94-9
货号 : A513135
分子式 : C4H13N5O2
纯度 : 98%
分子量 : 163.18
MDL号 : MFCD00210194
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 50 mg/mL(306.41 mM)，配合低频超声，并调节pH至9
生物活性
描述 DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor, characterized by a slow and sustained release of physiologically relevant levels of NO, exhibiting long-acting effects [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.13mL

1.23mL

0.61mL

30.64mL

6.13mL

3.06mL

61.28mL

12.26mL

6.13mL
参考文献

[1]Soichiro Sonoda, et al. Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells. Sci Rep. 2018 Feb 21;8(1):3419.

[2]S Shibuta, et al. A new nitric oxide donor, NOC-18, exhibits a nociceptive effect in the rat formalin model. EJ Neurol Sci. 1996 Sep 15;141(1-2):1-5

[3]Nandanwar N, et al. Growth medium and nitric oxide alter Mycobacterium abscessus morphotype and virulence. Microbiol Res. 2021 Dec;253:126887.

[4]Umbrasas D, et al. Nitric Oxide Donor NOC-18-Induced Changes of Mitochondrial Phosphoproteome in Rat Cardiac Ischemia Model. Medicina (Kaunas). 2019 Sep 24;55(10):631.