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D609 {[allProObj[0].p_purity_real_show]}

货号：A997327 同义名： Tricyclodecan-9-yl xanthogenate; D609 (potassium salt)

D609是一种竞争性磷脂酰胆碱特异性磷脂酶 C（PC-PLC）抑制剂，Ki 为 6.4 μM。它具有抗病毒和抗肿瘤作用，也能作为抗氧化保护剂。

D609 化学结构 CAS号：83373-60-8
D609 化学结构
CAS号：83373-60-8
D609 3D分子结构
CAS号：83373-60-8
D609 化学结构 CAS号：83373-60-8
D609 3D分子结构 CAS号：83373-60-8
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D609 纯度/质量文件 产品仅供科研

货号：A997327 标准纯度： {[allProObj[0].p_purity_real_show]}
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D609 生物活性

描述 D609 is a selective competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor (Ki = 6.4 μM) and antiviral and antitumor agent.

D609 细胞实验

Cell Line
Concentration Treated Time Description References
neonatal rat ventricular myocytes 100 μM 12 h Inhibits phospholipase C, preventing hypoxia-induced redistribution of PKCα and PKCε J Clin Invest. 1997 Jan 1;99(1):55-61
SKOV3 cells 53 μg/mL 24 h Inhibition of PC-plc activity, resulting in a 44% reduction of PCho content Cancer Res. 2010 Mar 1;70(5):2126-35
OVCAR3 cells 53 μg/mL 24 h Inhibition of PC-plc activity, resulting in a 30-40% reduction of PCho content and blocking cell proliferation Cancer Res. 2010 Mar 1;70(5):2126-35
human aorta smooth muscle cells (HASMCs) 100 μM 30 min inhibited IL-1β-induced MCP1 expression by blocking NF-κB translocation to the nucleus Exp Mol Med. 2009 Oct 31;41(10):757-64
A549 cells 350 μM 16 h Inhibited SMS activity, reversing the increase in SM levels induced by 2OHOA Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19569-74
microglia 10 μM 60 min D609 inhibits PC-PLC activity, blocking TNFα-induced PARP-1 activation and NF-κB transcriptional activation J Neuroinflammation. 2015 Dec 4;12:229
mouse cortical astrocytes 10 μM 60 min D609 inhibits PC-PLC activity, blocking TNFα-induced PARP-1 activation and NF-κB transcriptional activation J Neuroinflammation. 2015 Dec 4;12:229
Adult human RPE cells (hRPE) 10 μM 12-24 h D609 maintained hRPE cell morphology and expression of ZO-1 and MITF, preventing oxidative damage Signal Transduct Target Ther. 2020 Mar 4;5(1):20
Human fetal RPE cells (ftRPE) 10 μM 18-24 h D609 significantly enhanced the survival rate of ftRPE cells under severe oxidative stress and reduced the number of necrotic and apoptotic cells Signal Transduct Target Ther. 2020 Mar 4;5(1):20
ARPE-19 cells 10 μM 24 h D609 strongly protected ARPE-19 cells from SI-induced oxidative cell death and maintained normal cellular morphology Signal Transduct Target Ther. 2020 Mar 4;5(1):20

D609 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Mongolian gerbils Alzheimer's disease-related oxidative stress model Intraperitoneal injection 50 mg/kg Single injection, sampled after 1 hour D609 treatment significantly reduced oxidative stress-induced protein carbonyls, HNE-bound proteins, 3-NT levels, and cytochrome c release, and maintained the GSH/GSSG ratio. Free Radic Biol Med. 2006 Dec 1;41(11):1694-703
C57BL/6 mice SI-induced AMD mouse model Orbital venous plexus injection 25 mg/kg Single injection, observed up to 7 days post-injection D609 significantly protected the RPE layer from SI-induced damage and maintained retinal physiological function Signal Transduct Target Ther. 2020 Mar 4;5(1):20

D609 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00669734 Pancreatic Acinar Cell Carcino... 展开 >>ma Pancreatic Ductal Adenocarcinoma Stage III Pancreatic Cancer AJCC v6 and v7 Stage IV Pancreatic Cancer AJCC v6 and v7 收起 << Phase 1 Active, not recruiting - United States, New Jersey ... 展开 >> Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 收起 <<

D609 参考文献

[1]Zhou D, Lauderback CM, et al. D609 inhibits ionizing radiation-induced oxidative damage by acting as a potent antioxidant. J Pharmacol Exp Ther. 2001 Jul;298(1):103-9.

[2]Amtmann E. The antiviral, antitumoural xanthate D609 is a competitive inhibitor of phosphatidylcholine-specific phospholipase C. Drugs Exp Clin Res. 1996;22(6):287-94.

D609 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.75mL

0.75mL

0.38mL

18.76mL

3.75mL

1.88mL

37.53mL

7.51mL

3.75mL

D609 技术信息

CAS号83373-60-8
分子式C11H15KOS2
分子量 266.46
SMILES Code [S-]C(OC1C(C2)C3CCCC3C2C1)=S.[K+]
MDL No. MFCD00171401
别名 Tricyclodecan-9-yl xanthogenate; D609 (potassium salt); D-609 free
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, 2-8°C
溶解方案

DMSO: 105 mg/mL(394.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(7.51 mM)，配合低频超声助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案 一

Tags: D609 | 83373-60-8 | D 609 | D-609 | PC-PLC Inhibitor | Metabolic Enzyme/Protease | Phospholipase | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | D609 纯度/质量文件 | D609 生物活性 | D609 临床数据 | D609 参考文献 | D609 实验方案 | D609 技术信息

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