To assess the direct inhibitory effect of CyCl on colon cancer cells. Results showed that CyCl treatment significantly decreased cell proliferation in a time- and dose-dependent manner in all colon cancer cells.
Antioxidants (Basel). 2020 Mar 27;9(4):285
HT29 cells
10, 25, 50 µM
24, 48, 72 h
To assess the direct inhibitory effect of CyCl on colon cancer cells. Results showed that CyCl treatment significantly decreased cell proliferation in a time- and dose-dependent manner in all colon cancer cells.
Antioxidants (Basel). 2020 Mar 27;9(4):285
HCT116 cells
10, 25, 50 µM
24, 48, 72 h
To assess the direct inhibitory effect of CyCl on colon cancer cells. Results showed that CyCl treatment significantly decreased cell proliferation in a time- and dose-dependent manner in all colon cancer cells.
Antioxidants (Basel). 2020 Mar 27;9(4):285
HepG2 cells
4–256 μg/mL
24 h
Assessed cell viability and LDH release, showing no toxicity at 256 μg/mL
Virulence. 2022 Dec;13(1):1434-1445
HK-2 cells
50 µM
24 or 48 h
To evaluate the effects of Cyanidin Chloride on cholesterol metabolism and inflammation in HK-2 cells under high-glucose conditions. Results showed that Cyanidin Chloride significantly enhanced cholesterol efflux and ABCA1 expression, and reduced high-glucose-induced proinflammatory cytokine expression.
Drug Des Devel Ther. 2015 Sep 4;9:5099-113
H9C2 rat cardiomyocytes
200 μM
48 h
CyCl significantly attenuated Dox-induced cell damage, reduced intracellular ROS and peroxynitrite accumulation, and inhibited ferroptosis and apoptosis-related cell death
Adv Sci (Weinh). 2023 Oct;10(30):e2301136
Cyanidin Chloride/氯化矢车菊素 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6J mice
MRSA-induced pneumonia model
Subcutaneous injection
80 mg/kg
Started 1 h post-infection, every 12 h for 96 h
Assessed therapeutic effect on MRSA-induced pneumonia, showing survival rate increased from 10% to 50%
Virulence. 2022 Dec;13(1):1434-1445
Mice
Ethanol-induced gastric ulcer model
Oral
5, 10, and 20 mg/kg
Single dose, evaluated after 60 minutes
To investigate the gastroprotective role of cyanidin chloride in an ethanol-induced gastric ulcer model and its underlying mechanisms. Results showed that cyanidin chloride exhibited gastroprotective activity at different doses in male and female mice, but the effective dose varied depending on sex.
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