Cintirorgon, also known as LYC-55716, is a first-in-class selective oral bioactive RORγ agonist. Cintirorgon modulates gene expression in RORγ-expressing T-lymphocyte immune cells, resulting in enhanced effector function, decreased immunosuppression, reduced tumour growth, and improved survival[1][2].
Cintirorgon 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
C57BL/6 mice
Lewis lung carcinoma (LLC) model
Intraperitoneal injection
50 mg/kg
Once daily for two weeks
Evaluate the antitumor efficacy of LYC-55716 in the LLC model.
J Exp Clin Cancer Res. 2022 Apr 23;41(1):155
Sprague Dawley rats
Cecal ligation and puncture (CLP)-induced sepsis model
Intraperitoneal injection
150 mg/kg
Once daily for 7 days
To investigate the effect of LYC-55716 on intestinal immune function in septic rats.
Heliyon. 2023 Jun 28;9(7):e17766
Wistar rats
14-day-old neonatal rat infection model
Oral
10 mg/kg body weight
Once every two days, continued until 72 hours post-infection
To evaluate the protective effect of Cintirorgon on S. Typhimurium-infected neonatal rats, results showed that Cintirorgon significantly improved survival rates, alleviated weight loss and diarrhea symptoms, and reduced intestinal bacterial load.
Emerg Microbes Infect. 2024 Dec;13(1):2417867
Cintirorgon 动物研究
Animal study
Upon oral administration, Cintirorgon selectively binds to the nuclear receptor transcription factor RORγ, forming a receptor complex that translocates to the nucleus and binds to ROREs to enhance the function, proliferation and survival of Th17 and Tc17 cells. RORγ is a nuclear receptor transcription factor involved in the differentiation of Th17/Tc17 and plays a key role in immune activation[1].
United States, Colorado
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United States, Michigan
Lycera Investigational Site
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Ann Arbor, Michigan, United States, 48109
United States, Tennessee
Lycera Investigational Site
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Nashville, Tennessee, United States, 37203
United States, Washington
Lycera Investigational Site
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United States, Colorado
... 展开 >>
Lycera Investigational Site
Recruiting
Aurora, Colorado, United States, 80045
United States, Michigan
Lycera Investigational Site
Recruiting
Ann Arbor, Michigan, United States, 48109
United States, Tennessee
Lycera Investigational Site
Recruiting
Nashville, Tennessee, United States, 37203
United States, Washington
Lycera Investigational Site
Recruiting
Seattle, Washington, United States, 98109 收起 <<
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