There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Cetrimonium bromide (CTAB), a quaternary ammonium compound, serves as an orally active cationic surfactant. It is recognized for its toxicity and anticancer properties. CTAB modulates cell migration and invasion by influencing both the canonical and non-canonical TGF-β signaling pathways, and it is also employed in DNA extraction processes[1].[2].[3].[4].
体内研究
When administered intraperitoneally at 5 mg/kg daily for five consecutive days, it eradicates the tumor-forming ability of FaDu cells and delays the growth of established tumors in mice bearing FaDu cell tumors[2].
For long-term exposure, Cetrimonium bromide administered at doses of 10-45 mg/kg in drinking water once daily for one year exhibits subacute and chronic toxicity in rats[3].
体外研究
In studies with SK-HEP-1 cells, concentrations of Cetrimonium bromide ranging from 1-5 μM over 24 hours do not affect cell growth[1].
However, at a concentration of 5 μM and over a duration of 16-24 hours, CTAB significantly reduces cellular migration and invasion in these cells[1].
Additionally, Cetrimonium bromide at 5 μM over 24 hours leads to the suppression of MMP-2 and MMP-9 protein expression, while increasing the levels of TIMP-1 and TIMP-2. It also decreases the protein expression of key signaling molecules such as Rac1, cdc42, and RhoA in SK-HEP-1 cells[1].
In the context of cancer therapy, CTAB at a concentration of 5 μM over 12-72 hours induces apoptosis in human head and neck cancer (HNC) cells[2].
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