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CFTR(inh)-172 {[allProObj[0].p_purity_real_show]}

货号：A285038 同义名： CFTR Inhibitor-172; Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor 172

CFTR(inh)-172是一种可逆抑制剂，能够在不到 2 分钟内通过电压独立方式抑制 CFTR 短路电流，Ki 值约为 300 nM。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
CFTR(inh)-172 化学结构 CAS号：307510-92-5
CFTR(inh)-172 化学结构
CAS号：307510-92-5
CFTR(inh)-172 3D分子结构
CAS号：307510-92-5
CFTR(inh)-172 化学结构 CAS号：307510-92-5
CFTR(inh)-172 3D分子结构 CAS号：307510-92-5
规格 价格 会员价 库存 数量
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CFTR(inh)-172 纯度/质量文件 产品仅供科研

货号：A285038 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nature, 2025, 645, 793-800. Ambeed. [ A201204 , A444152 , A344107 , A952055 ]
• Cell, 2025. Ambeed. [ A122167 ]
• Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]
• Sig. Transduct. Target. Ther., 2025, 10, 257. Ambeed. [ A104916 ]
• Nat. Nanotechnol., 2025. Ambeed. [ A243018 , A1216705 , A522597 , A125401 , A1355641 ]
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产品名称 CFTR ↓ 其他靶点 纯度
Ataluren ✔ 98%
Lumacaftor ++++

F508del-CFTR, EC50: 0.1 μM

 		98%
CFTR(inh)-172 +++

CFTR, Ki: 300 nM

 		99%+
GlyH-101 +

CFTR, Ki: 4.3 μM

 		99%+
IOWH-032 ++

CFTR, IC50: 1.01 μM

 		99%+
Tezacaftor ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

CFTR(inh)-172 生物活性

靶点

  • CFTR

    CFTR, Ki:300 nM
描述 The cystic fibrosis transmembrane conductance regulator (CFTR) protein is cAMP-activated epithelial Cl- channel required for fluid secretion in the intestine and airways. CFTR(inh)-172 reversibly inhibited CFTR short-circuit current in a voltage-independent manner with a KI of approximately 300nM. CFTR(inh)-172 significantly inhibited CFTR at dosages of 0.3-0.6μM. In CFTR-expressing FRT cells, treatment with CFTR(inh)-172 led to a dose-dependent inhibition of short-circuit current with a Kd value of approximately 300nM. CFTR(inh)-172 at 5μM did not block Ca2+-activated Cl- secretion in polarized human bronchial epithelial cell or volume-activated Cl- currents in FRT cells. A single intraperitoneal injection of CFTR(inh)-172 (250μg/kg) in mice before cholera toxin infusion prevented fluid accumulation in the toxin-treated intestinal loops[3].
作用机制 CFTR(inh)-172 is a potent blocker of the CFTR Cl- channel that reversibly inhibits CFTR short-circuit current[3].

CFTR(inh)-172 细胞实验

Cell Line
Concentration Treated Time Description References
Renal proximal cells (PCT cells) 5 µM 24 hours CFTR(inh)-172 prevents cisplatin-induced cell death and apoptosis by modulating the intracellular reactive oxygen species (ROS) balance and glutathione (GSH) concentration. Cell Death Dis. 2013 Oct 3;4(10):e817.
A549 cells 5 µM 24 hours CFTR(inh)-172 does not impair the antitumor activity of cisplatin in A549 cancer cells. Cell Death Dis. 2013 Oct 3;4(10):e817.
Human peripheral blood neutrophils 0.5, 1, 2.5, 5 µM 4 hours CFTR(inh)-172 increased CitH3 protein expression and dsDNA fluorescence staining in a concentration-dependent manner, indicating its promotion of NET formation. Acta Pharmacol Sin. 2022 Nov;43(11):2848-2861.
FRT cells 20 µM Inhibit CFTR channel activity and reverse the increase in Cl- current induced by anthraquinone compounds Acta Pharmacol Sin. 2011 Jun;32(6):834-9.

CFTR(inh)-172 动物实验

Species
Animal Model
Administration Dosage Frequency Description References
Rats Cisplatin-induced nephrotoxicity model Intraperitoneal injection 1 mg/kg Single dose, 30 minutes before cisplatin injection CFTR(inh)-172 pretreatment significantly prevented cisplatin-induced nephrotoxicity, improved renal function, and reduced oxidative stress. Cell Death Dis. 2013 Oct 3;4(10):e817.
Mice Wild-type C57BL/6J mice Intravenous injection 2 mg/kg 24 hours CFTR(inh)-172 increased neutrophil [Cl?]i and dsDNA release, indicating its promotion of NET formation in vivo. Acta Pharmacol Sin. 2022 Nov;43(11):2848-2861.
SD rats Closed colonic loop model Intraperitoneal injection 40 µmol/L Single dose, lasted for 6 hours Inhibit fluid accumulation in the colon induced by rhein Acta Pharmacol Sin. 2011 Jun;32(6):834-9.

CFTR(inh)-172 参考文献

[1]Lu M, Ding C. CFTR-mediated Cl(-) transport in the acinar and duct cells of rabbit lacrimal gland. Curr Eye Res. 2012 Aug;37(8):671-7.

[2]Ma T, Thiagarajah JR, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec;110(11):1651-8.

[3]Ma T, Thiagarajah JR, Yang H, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002;110(11):1651-1658.

CFTR(inh)-172 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.21mL

2.44mL

1.22mL

24.43mL

4.89mL

2.44mL

CFTR(inh)-172 技术信息

CAS号307510-92-5
分子式C18H10F3NO3S2
分子量 409.4
SMILES Code O=C1N(C2=CC=CC(C(F)(F)F)=C2)C(S/C1=C\C3=CC=C(C(O)=O)C=C3)=S
MDL No. MFCD01164609
别名 CFTR Inhibitor-172; Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor 172; CFTRinh-172
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Sealed in dry, 2-8°C
溶解方案

DMSO: 50 mg/mL(122.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二

Tags: CFTR(inh)-172 | 307510-92-5 | CFTR | Autophagy | CFTR Inhibitor | Membrane Transporter/Ion Channel | Autophagy | CFTR | Autophagy | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | CFTR(inh)-172 纯度/质量文件 | CFTR(inh)-172 亚型比较 | CFTR(inh)-172 生物活性 | CFTR(inh)-172 参考文献 | CFTR(inh)-172 实验方案 | CFTR(inh)-172 技术信息

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