Bumetanide|PF 1593; Ro 10-6338|NKCC|for research only|Ambeed

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Bumetanide/布美他尼 {[allProObj[0].p_purity_real_show]}

货号：A266088 同义名： PF 1593; Ro 10-6338

Bumetanide is an NKCC1 inhibitor used in brain disorders, but poorly crosses the blood-brain barrier.

Bumetanide/布美他尼化学结构
CAS号：28395-03-1

Bumetanide/布美他尼 3D分子结构
CAS号：28395-03-1

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Bumetanide/布美他尼纯度/质量文件产品仅供科研

货号：A266088 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Science, 2025, 387(6729): eadp5637. Ambeed. [ A875019 ]; • Nat. Electron., 2025, 8, 66-74. Ambeed. [ A100095 ]; • Adv. Mater., 2025, 2416621. Ambeed. [ A255324 , A420052 ]; • Adv. Mater., 2025, 2410493. Ambeed. [ A838608 ]; • Adv. Mater., 2025, 2420319. Ambeed. [ A106129 ]; 更多 >

Bumetanide/布美他尼生物活性

描述	Bumetanide is an inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM.

Bumetanide/布美他尼临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03296813	Heart Failure	Phase 3	Recruiting	August 14, 2022	-
NCT00608491	Heart Failure	Phase 3	Completed	-	United States, Arizona ... 展开 >> Mayo Clinic Arizona Phoenix, Arizona, United States, 85054 United States, Georgia Morehouse School of Medicine Atlanta, Georgia, United States, 30310 United States, Minnesota Minnesota Heart Failure Network Minneapolis, Minnesota, United States, 55415 Mayo Clinic Rochester, Minnesota, United States, 55905 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27705 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 United States, Utah University of Utah Health Sciences Center Murray, Utah, United States, 84107 United States, Vermont University of Vermont - Fletcher Allen Health Care Burlington, Vermont, United States, 05401 Canada, Quebec Montreal Heart Institute Montreal, Quebec, Canada, H1T - 1C8 收起 <<
NCT00608491	-		Completed	-	-

Bumetanide/布美他尼参考文献

[1]Sandstrom PE. Evidence for diabetogenic action of bumetanide in mice. Eur J Pharmacol. 1988 May 20;150(1-2):35-41.

[2]Frelin C, Chassande O, et al. Biochemical characterization of the Na+/K+/Cl- co-transport in chick cardiac cells. Biochem Biophys Res Commun. 1986 Jan 14;134(1):326-31.

Bumetanide/布美他尼实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.74mL

0.55mL

0.27mL

13.72mL

2.74mL

1.37mL

27.44mL

5.49mL

2.74mL

Bumetanide/布美他尼技术信息

CAS号	28395-03-1
分子式	C₁₇H₂₀N₂O₅S
分子量	364.42
SMILES Code	O=C(O)C1=CC(NCCCC)=C(OC2=CC=CC=C2)C(S(=O)(N)=O)=C1
MDL No.	MFCD00078949

别名	PF 1593; Ro 10-6338
运输	蓝冰
InChI Key	MAEIEVLCKWDQJH-UHFFFAOYSA-N
Pubchem ID	2471

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place, inert atmosphere, room temperature

溶解方案

细胞实验：

DMSO: 105 mg/mL(288.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03296813	Heart Failure	Phase 3	Recruiting	August 14, 2022	-
NCT00608491	Heart Failure	Phase 3	Completed	-	United States, Arizona ... 展开 >> Mayo Clinic Arizona Phoenix, Arizona, United States, 85054 United States, Georgia Morehouse School of Medicine Atlanta, Georgia, United States, 30310 United States, Minnesota Minnesota Heart Failure Network Minneapolis, Minnesota, United States, 55415 Mayo Clinic Rochester, Minnesota, United States, 55905 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27705 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 United States, Utah University of Utah Health Sciences Center Murray, Utah, United States, 84107 United States, Vermont University of Vermont - Fletcher Allen Health Care Burlington, Vermont, United States, 05401 Canada, Quebec Montreal Heart Institute Montreal, Quebec, Canada, H1T - 1C8 收起 <<
NCT00608491	-		Completed	-	-
NCT01138683	Acute Decompensated Heart Fail... 展开 >>ure 收起 <<	Phase 3	Completed	-	Belgium ... 展开 >> University Hospital Ghent Ghent, Belgium 收起 <<
NCT03481881	-		Recruiting	August 14, 2023	United States, North Carolina ... 展开 >> Duke University Recruiting Durham, North Carolina, United States, 27710 Contact: Rachel Greenberg, MD 919-668-4725 rachel.greenberg@duke.edu 收起 <<
NCT00684489	Hypertension	Not Applicable	Completed	-	-
NCT03107507	Neonatal Seizures	Phase 4	Recruiting	December 30, 2017	Egypt ... 展开 >> Cairo University Children's Hospital (Abulreesh) Recruiting Cairo Governorate, Egypt Contact: Yara Shaheen 收起 <<
NCT03302910	Acute Heart Failure	Phase 2 Phase 3	Recruiting	June 30, 2021	United States, Indiana ... 展开 >> Indiana University Recruiting Indianapolis, Indiana, United States, 46201 Contact: Peter S Pang, MD 312-515-4025 ppang@iu.edu Contact: Mette Cole, MD 317-880-3900 metcole@iu.edu Principal Investigator: Peter S Pang, MD United States, Michigan Wayne State University Recruiting Detroit, Michigan, United States, 48201 Contact: Phillip D Levy, MD Beaumont Health System Recruiting Royal Oak, Michigan, United States, 48073 Contact: Ryan Paternoster, CCRP Principal Investigator: David Berger, MD United States, North Carolina Wake Forest School of Medicine Recruiting Winston-Salem, North Carolina, United States, 27157 Contact: Stephanie Elliott Principal Investigator: Simon Mahler, MD, MS United States, Ohio Ohio State University Recruiting Columbus, Ohio, United States, 43210 Contact: Michael Hill, RN, BSN Principal Investigator: Lauren Southerland, MD United States, Pennsylvania Allegheny Health Network Recruiting Pittsburgh, Pennsylvania, United States, 15212 Contact: Kelly Szabo, MPH, CCRC Principal Investigator: Arvindo Venkat, MD United States, Tennessee Vanderbilt University Medical Center Recruiting Nashville, Tennessee, United States, 37212 Contact: Sean P Collins, MD 收起 <<
NCT02476409	Congestive Heart Failure	Phase 4	Recruiting	January 2019	United States, North Carolina ... 展开 >> University of North Carolina at Chapel Hill Recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Kirkwood F Adams, MD 919-843-5223 kfa@med.unc.edu Principal Investigator: Kirkwood F Adams, MD 收起 <<
NCT01973335	Heart Failure	Phase 4	Completed	-	Belgium ... 展开 >> Ziekenhuis Oost-Limburg Genk, Limburg, Belgium, 3600 University Hospital Leuven Leuven, Vlaams-Brabant, Belgium, 3000 收起 <<
NCT02546583	Heart Failure	Not Applicable	Recruiting	July 2025	United States, Connecticut ... 展开 >> Yale University Recruiting New Haven, Connecticut, United States Contact: Jeffrey Testani, MD Jeffrey.Testani@yale.edu 收起 <<
NCT02593526	Chronic Kidney Insufficiency	Not Applicable	Recruiting	December 2019	United States, New Mexico ... 展开 >> Dialysis Clinic Inc. - Indian School Recruiting Albuquerque, New Mexico, United States, 87106 Contact: Christopher Zima 505-272-6603 CPZima@salud.unm.edu 收起 <<
NCT01457053	-		Terminated(Population not avai... 展开 >>lable for enrollment) 收起 <<	-	-
NCT03709160	Heart Failure ... 展开 >> Congestive Heart Failure 收起 <<	Phase 4	Recruiting	October 15, 2019	Mexico ... 展开 >> Centro de Insuficiencia Cardiaca Instituto Nacional de Cardiologia Recruiting Mexico City, Mexico, 14080 Contact: CHUQUIURE-VALENZUELA EDUARDO, MD, MSc +5215554017407 echuquiurev@yahoo.com Principal Investigator: EDUARDO CHUQUIURE-VALENZUELA, MD MSc Sub-Investigator: OSCAR FISCAL-LOPEZ, MD 收起 <<
NCT02288819	Heart Failure	Not Applicable	Completed	-	Belgium ... 展开 >> Ziekenhuis Oost-Limburg Genk, Limburg, Belgium, 3600 收起 <<
NCT03715166	Autism Spectrum Disorder (ASD)	Phase 3	Recruiting	April 2021	-
NCT02765009	Fluid Shifts ... 展开 >>Critical Care 收起 <<	Not Applicable	Recruiting	July 2019	France ... 展开 >> Hopital Nord Franche-Comté Not yet recruiting Belfort, France, 90000 Contact: Julio Badie, MD 0033(0)384985667 Julio.badie@hnfc.fr Centre Hospitalier Universitaire Recruiting Dijon, France, 21000 Contact: Jean-Pierre Quenot, MD, PhD 0033(0)380293751 jean-pierre.quenot@chu-dijon.fr Centre Hospitalier Universitaire Not yet recruiting Lyon, France, 69000 Contact: Laurent Argaud, MD, PhD 0033(0)472110015 laurent.argaud@chu-lyon.fr Centre Hospitalier Régional Recruiting Metz, France, 57000 Contact: Guillaume Louis, MD 0033(0)387553569 gus_louis@yahoo.fr Centre Hospitalier Régional et Universitaire Recruiting Nancy, France, 54000 Contact: Pierre-Edouard Bollaert, MD,PhD 0033(0)383851494 pe.bollaert@chru-nancy.fr Centre Hospitalier Régional et Universitaire Recruiting Nancy, France, 54000 Contact: Claire Charpentier, MD 0033(0)383852037 c.charpentier@chru-nancy.fr Groupe Hospitalier Saint Joseph Recruiting Paris, France, 75000 Contact: Cédric Bruel, MD 0033(0)144123415 cbruel@hpsj.fr Centre Hospitalier intercommunal Not yet recruiting Poissy, France, 78303 Contact: Hervé Outin, MD 0033(0)139275202 outin@chi-poissy-st-germain.fr Centre Hospitalier Régional et Universitaire Recruiting Strasbourg, France, 67000 Contact: Francis Schneider, MD, PhD 0033(0)388127922 francis.schneider@chru-strasbourg.fr CentreHospitalier Régional et universitaire Not yet recruiting Strasbourg, France, 67000 Contact: Ferhat Meziani, MD, PhD 0033(0)388116768 ferhat.meziani@chru-strasbour.fr Centre Hospitalier Régional Not yet recruiting Thionville, France, 57000 Contact: Michel Bemer, MD 0033(0)382558239 m.bemer@chr-metz-thionville.fr Centre Hospitalier Recruiting Verdun, France, 55100 Contact: Bruno Maire, MD 0033(3)329838485 bmaire@ch-verdun.fr 收起 <<
NCT01078714	Autistics Children	Phase 3	Completed	-	France ... 展开 >> Lemonnier Brest, France, 29609 Chevreuil Rennes, France, 35703 DUPIN Vannes, France, 56000 收起 <<
NCT01457053	Acute Decompensated Heart Fail... 展开 >>ure 收起 <<	Not Applicable	Terminated(Population not avai... 展开 >>lable for enrollment) 收起 <<	-	United States, Ohio ... 展开 >> University of Cincinnati/University Hospital Cincinnati, Ohio, United States, 45221 University Hospital Cincinnati, Ohio, United States, 45267 收起 <<
NCT00372762	Heart Failure	Phase 3	Withdrawn(Due to changes withi... 展开 >>n the research program this study is not feasible at this time) 收起 <<	June 2013	Canada, Ontario ... 展开 >> University Hospital, London Health Sciences Centre London, Ontario, Canada, N6A 5A5 收起 <<
NCT01434225	Neonatal Seizures	Phase 1 Phase 2	Completed	-	Ireland ... 展开 >> Cork University Maternity Hospital Cork, Ireland Netherlands Erasmus Universitair Medisch Centrum Rotterdam Rotterdam, Netherlands University Medical Centre Utrecht Utrecht, Netherlands, 3508 AB Sweden Karolinska Institutet and University Hospital Stockholm, Sweden Uppsala University Hospital Uppsala, Sweden United Kingdom Leeds General Infirmary Leeds, United Kingdom University College London Hospitals NHS Foundation Trust London, United Kingdom 收起 <<
NCT00930865	Type 2 Diabetes Mellitus	Phase 1	Completed	-	United States, Texas ... 展开 >> Ppd Development, Lp Austin, Texas, United States, 78744 收起 <<
NCT03156153	Autism Spectrum Disorder	Phase 2	Not yet recruiting	January 2019	-
NCT02582476	Hypokalemic Periodic Paralysis	Phase 2	Terminated(Slow enrolment and ... 展开 >>end of funding) 收起 <<	-	United Kingdom ... 展开 >> MRC Centre for Neuromuscular Disorders London, United Kingdom, WC1N 3BG 收起 <<
NCT03715153	Autism Spectrum Disorder (ASD)	Phase 3	Recruiting	April 2021	-
NCT00830531	Seizures	Phase 1	Active, not recruiting	December 2018	United States, Massachusetts ... 展开 >> Tufts Floating Hospital for Children at Tufts Medical Center Boston, Massachusetts, United States, 02111 Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Boston Children's Hospital Boston, Massachusetts, United States, 02115 Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 收起 <<
NCT03107416	Unresectable Hepatocellular Ca... 展开 >>rcinoma 收起 <<	Phase 1 Phase 2	Recruiting	April 5, 2019	United States, New Jersey ... 展开 >> Memoral Sloan Kettering Basking Ridge Recruiting Basking Ridge, New Jersey, United States, 07920 Contact: Hooman Yarmohammadi, MD 212-639-2234 Memorial Sloan Kettering Monmouth Recruiting Middletown, New Jersey, United States, 07748 Contact: Hooman Yarmohammadi, MD 212-639-2234 Memorial Sloan Kettering Bergen Recruiting Montvale, New Jersey, United States, 07645 Contact: Hooman Yarmohammadi, MD 212-639-2234 United States, New York Memorial Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: Hooman Yarmohammadi, MD 212-639-2234 Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Hooman Yarmohammadi, MD 212-639-2234 Contact: Karen T. Brown, MD 212-639-5882 Principal Investigator: Hooman Yarmohammadi, MD Memorial Sloan Kettering Rockville Centre Recruiting Rockville Centre, New York, United States, 11570 Contact: Hooman Yarmohammadi, MD 212-639-2234 收起 <<
NCT02947880	Autistic Disorder	Phase 2	Withdrawn(the recently feasibi... 展开 >>lity study shows that the number of patients is insufficient in the centers) 收起 <<	June 2020	-

Bumetanide/布美他尼 {[allProObj[0].p_purity_real_show]}

Bumetanide/布美他尼纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Bumetanide/布美他尼质控信息

Bumetanide/布美他尼生物活性

Bumetanide/布美他尼临床研究

Bumetanide/布美他尼参考文献

Bumetanide/布美他尼实验方案

Bumetanide/布美他尼技术信息

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Bumetanide/布美他尼 {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

Bumetanide/布美他尼 质控信息

Bumetanide/布美他尼 生物活性

Bumetanide/布美他尼 临床研究

Bumetanide/布美他尼 参考文献

Bumetanide/布美他尼 实验方案

Bumetanide/布美他尼 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Bumetanide/布美他尼纯度/质量文件产品仅供科研

Bumetanide/布美他尼质控信息

Bumetanide/布美他尼生物活性

Bumetanide/布美他尼临床研究

Bumetanide/布美他尼参考文献

Bumetanide/布美他尼实验方案

Bumetanide/布美他尼技术信息