Bumetanide

产品说明书

Print
Chemical Structure| 28395-03-1 同义名 : PF 1593; Ro 10-6338
CAS号 : 28395-03-1
货号 : A266088
分子式 : C17H20N2O5S
纯度 : 98%
分子量 : 364.42
MDL号 : MFCD00078949
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(288.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Bumetanide is an inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03296813 Heart Failure Phase 3 Recruiting August 14, 2022 -
NCT00608491 Heart Failure Phase 3 Completed - United States, Arizona ... 展开 >> Mayo Clinic Arizona Phoenix, Arizona, United States, 85054 United States, Georgia Morehouse School of Medicine Atlanta, Georgia, United States, 30310 United States, Minnesota Minnesota Heart Failure Network Minneapolis, Minnesota, United States, 55415 Mayo Clinic Rochester, Minnesota, United States, 55905 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27705 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 United States, Utah University of Utah Health Sciences Center Murray, Utah, United States, 84107 United States, Vermont University of Vermont - Fletcher Allen Health Care Burlington, Vermont, United States, 05401 Canada, Quebec Montreal Heart Institute Montreal, Quebec, Canada, H1T - 1C8 收起 <<
NCT00608491 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.74mL

0.55mL

0.27mL

13.72mL

2.74mL

1.37mL

27.44mL

5.49mL

2.74mL
参考文献

[1]Sandstrom PE. Evidence for diabetogenic action of bumetanide in mice. Eur J Pharmacol. 1988 May 20;150(1-2):35-41.

[2]Frelin C, Chassande O, et al. Biochemical characterization of the Na+/K+/Cl- co-transport in chick cardiac cells. Biochem Biophys Res Commun. 1986 Jan 14;134(1):326-31.