There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
BEL completely blocked ATP-stimulated DHA release, indicating that DHA release is mediated by iPLA2.
Br J Pharmacol. 2003 Jul;139(5):1014-22
ARPE-19 cells
10 μM and 25 μM
To investigate the effect of Bromoenol lactone on phagocytosis in ARPE-19 cells. Results showed that BEL pretreatment significantly inhibited rhodopsin degradation and β-hydroxybutyrate release.
Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):30
rat retinal neurons
5 μM
30 min
Inhibition of iPLA2 to prevent DHA release from phospholipids, thereby blocking DHA's protective effect against oxidative stress-induced apoptosis in retinal neurons
J Lipid Res. 2013 Aug;54(8):2236-2246
BV-2 microglial cells
5 μM
6 h
BEL significantly decreased the basal levels of 4-HHE in BV-2 microglial cells, indicating the role of iPLA2 in endogenous DHA metabolism. However, BEL only partially inhibited the increase in 4-HHE induced by exogenous DHA or DHA + LPS.
J Neuroinflammation. 2018 Jul 9;15(1):202
Barth syndrome patients’ lymphoblasts
2.5 μM
48 h
partially restores their cardiolipin homeostasis
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2337-41
normal human epidermal keratinocytes (NHEKs)
10 or 20 µM
30 min
To investigate the role of iPLA2 in agonist-induced calcium entry (ACE) in keratinocytes. Results showed that BEL treatment impaired Ca2+ entry in NHEKs.
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