 
        
        
        Bradykinin 是一种有效的内皮依赖性血管扩张剂,能够降低血压。它还可以引起支气管和肠道非血管平滑肌的收缩,增加血管通透性,并参与疼痛机制的研究。
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 HazMat Fee + There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
| Type | HazMat fee for 500 gram (Estimated) | 
| Excepted Quantity | USD 0.00 | 
| Limited Quantity | USD 15-60 | 
| Inaccessible (Haz class 6.1), Domestic | USD 80+ | 
| Inaccessible (Haz class 6.1), International | USD 150+ | 
| Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ | 
| Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ | 
 
                                 
                                
                            

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| Concentration | Treated Time | Description | References | |
| human coronary arterioles (HCAs) | 1 µM | To assess BK-induced ROS production and its source. Results showed that BK induces ROS production via NADPH oxidase. | Arterioscler Thromb Vasc Biol. 2009 May;29(5):739-45 | |
| human coronary artery endothelial cells (HCAECs) | 1 µM | To assess BK-induced ROS production and its source. Results showed that BK induces ROS production via NADPH oxidase, not the mitochondrial electron transport chain. | Arterioscler Thromb Vasc Biol. 2009 May;29(5):739-45 | |
| human cardiac c-Kit+ progenitor cells (hCPCs) | 1, 3, 10 nM | 1 h | BK suppressed H2O2-induced hCPCs apoptosis and ROS production in a concentration-dependent manner by promoting pAkt and Bcl-2 expression and reducing cleaved caspase 3 and Bax expression. Moreover, BK restrained the H2O2-induced cell autophagy by decreasing LC3II/I, Beclin1, and ATG5 expression and increasing P62 expression. | Stem Cell Res Ther. 2021 Aug 5;12(1):437 | 
| T84 cells | 10 nM | To study the effect of bradykinin on ion transport in T84 cells, results showed that bradykinin promotes Cl- secretion via activation of B2 receptors. | Br J Pharmacol. 2008 Oct;155(4):558-66 | |
| guinea-pig tracheal smooth muscle cells | 0.1 nM – 10 μM | 10 min | Investigate the effect of Bradykinin on Na+-K+ pump activity, showing a concentration-dependent increase in ouabain-sensitive 86Rb+ uptake with an EC50 of 3 nM. | Br J Pharmacol. 2001 Aug;133(8):1339-45 | 
| Porcine coronary arteries | 0.1 nM–1 μM | To investigate the bradykinin-induced vasorelaxation and its mechanisms, results showed that bradykinin causes vasodilation via stimulation of guanylyl cyclase and/or Ca2+-dependent K+-channels | Br J Pharmacol. 2000 Sep;131(2):195-202 | |
| Wildtype mouse hearts | 1 μM | To evaluate the BK-induced vasodilation, which was mediated largely by NO in WT hearts and by CYP450 metabolites in eNOS -/- hearts | Br J Pharmacol. 2002 Feb;135(3):631-8 | 
| 计算器 | ||||
| 存储液制备 |  | 1mg | 5mg | 10mg | 
| 1 mM 5 mM 10 mM | 0.94mL 0.19mL 0.09mL | 4.72mL 0.94mL 0.47mL | 9.43mL 1.89mL 0.94mL | |
| CAS号 | 58-82-2 | 
| 分子式 | C50H73N15O11 | 
| 分子量 | 1060.21 | 
| SMILES Code | O=C([C@H]1N(CCC1)C([C@@H](N)CCCNC(N)=N)=O)N2[C@@H](CCC2)C(NCC(N[C@H](C(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)=O)=O | 
| MDL No. | MFCD00076258 | 
| 别名 | Bradykinin游离态 | 
| 运输 | 蓝冰 | 
| 存储条件 | In solvent -20°C: 3-6个月 -80°C: 12个月 Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C | 
| 溶解方案 | H2O: 100 mg/mL(94.32 mM) 
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