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Bradykinin/缓激肽 {[allProObj[0].p_purity_real_show]}

货号:A725345 同义名: Bradykinin游离态

Bradykinin 是一种有效的内皮依赖性血管扩张剂,能够降低血压。它还可以引起支气管和肠道非血管平滑肌的收缩,增加血管通透性,并参与疼痛机制的研究。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Bradykinin/缓激肽 化学结构 CAS号:58-82-2
Bradykinin/缓激肽 化学结构
CAS号:58-82-2
Bradykinin/缓激肽 3D分子结构
CAS号:58-82-2
Bradykinin/缓激肽 化学结构 CAS号:58-82-2
Bradykinin/缓激肽 3D分子结构 CAS号:58-82-2
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Bradykinin/缓激肽 纯度/质量文件 产品仅供科研

货号:A725345 标准纯度: {[allProObj[0].p_purity_real_show]}
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Bradykinin/缓激肽 细胞实验

Cell Line
Concentration Treated Time Description References
human coronary arterioles (HCAs) 1 µM To assess BK-induced ROS production and its source. Results showed that BK induces ROS production via NADPH oxidase. Arterioscler Thromb Vasc Biol. 2009 May;29(5):739-45
human coronary artery endothelial cells (HCAECs) 1 µM To assess BK-induced ROS production and its source. Results showed that BK induces ROS production via NADPH oxidase, not the mitochondrial electron transport chain. Arterioscler Thromb Vasc Biol. 2009 May;29(5):739-45
human cardiac c-Kit+ progenitor cells (hCPCs) 1, 3, 10 nM 1 h BK suppressed H2O2-induced hCPCs apoptosis and ROS production in a concentration-dependent manner by promoting pAkt and Bcl-2 expression and reducing cleaved caspase 3 and Bax expression. Moreover, BK restrained the H2O2-induced cell autophagy by decreasing LC3II/I, Beclin1, and ATG5 expression and increasing P62 expression. Stem Cell Res Ther. 2021 Aug 5;12(1):437
T84 cells 10 nM To study the effect of bradykinin on ion transport in T84 cells, results showed that bradykinin promotes Cl- secretion via activation of B2 receptors. Br J Pharmacol. 2008 Oct;155(4):558-66
guinea-pig tracheal smooth muscle cells 0.1 nM – 10 μM 10 min Investigate the effect of Bradykinin on Na+-K+ pump activity, showing a concentration-dependent increase in ouabain-sensitive 86Rb+ uptake with an EC50 of 3 nM. Br J Pharmacol. 2001 Aug;133(8):1339-45
Porcine coronary arteries 0.1 nM–1 μM To investigate the bradykinin-induced vasorelaxation and its mechanisms, results showed that bradykinin causes vasodilation via stimulation of guanylyl cyclase and/or Ca2+-dependent K+-channels Br J Pharmacol. 2000 Sep;131(2):195-202
Wildtype mouse hearts 1 μM To evaluate the BK-induced vasodilation, which was mediated largely by NO in WT hearts and by CYP450 metabolites in eNOS -/- hearts Br J Pharmacol. 2002 Feb;135(3):631-8

Bradykinin/缓激肽 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.94mL

0.19mL

0.09mL

4.72mL

0.94mL

0.47mL

9.43mL

1.89mL

0.94mL

Bradykinin/缓激肽 技术信息

CAS号58-82-2
分子式C50H73N15O11
分子量 1060.21
SMILES Code O=C([C@H]1N(CCC1)C([C@@H](N)CCCNC(N)=N)=O)N2[C@@H](CCC2)C(NCC(N[C@H](C(N[C@@H](CO)C(N3[C@@H](CCC3)C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)=O)=O
MDL No. MFCD00076258
别名 Bradykinin游离态
运输蓝冰
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

溶解方案

H2O: 100 mg/mL(94.32 mM)

配制的工作液建议现用现配,短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案 一
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