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/ Bedaquiline fumarate/贝达喹啉富马酸盐

Bedaquiline fumarate/贝达喹啉富马酸盐 {[allProObj[0].p_purity_real_show]}

货号：A648653 同义名： R403323; TMC207 fumarate

Bedaquiline fumarate是一种二芳基喹啉类抗生素，靶向 ATP 合成酶用于治疗结核分枝杆菌感染，具有抗菌效果并在耐药性结核的治疗中显示出潜力。

Bedaquiline fumarate/贝达喹啉富马酸盐 化学结构 CAS号：845533-86-0
Bedaquiline fumarate/贝达喹啉富马酸盐 化学结构
CAS号：845533-86-0
Bedaquiline fumarate/贝达喹啉富马酸盐 3D分子结构
CAS号：845533-86-0
Bedaquiline fumarate/贝达喹啉富马酸盐 化学结构 CAS号：845533-86-0
Bedaquiline fumarate/贝达喹啉富马酸盐 3D分子结构 CAS号：845533-86-0
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Bedaquiline fumarate/贝达喹啉富马酸盐 纯度/质量文件 产品仅供科研

货号：A648653 标准纯度： {[allProObj[0].p_purity_real_show]}
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Bedaquiline fumarate/贝达喹啉富马酸盐 生物活性

描述 Bedaquiline hinders the proliferation of TDR M. tuberculosis strains, showing MIC values within the range of 0.125 to 0.5 mg/LL[1]. Bedaquiline demonstrates its highest efficacy against Mycobacterium avium among slowly growing mycobacteria (SGM), with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), both Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) appear to be more susceptible to bedaquiline compared to Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Additionally, bedaquiline demonstrates moderate in vitro activity against non-tuberculous mycobacteria (NTM) species[2]. Bedaquiline exhibits outstanding in vitro activity against Mycobacterium tuberculosis, including strains that are multidrug-resistant[3].
体外研究

Bedaquiline hinders the proliferation of TDR M. tuberculosis strains, showing MIC values within the range of 0.125 to 0.5 mg/LL[1].

Bedaquiline demonstrates its highest efficacy against Mycobacterium avium among slowly growing mycobacteria (SGM), with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), both Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) appear to be more susceptible to bedaquiline compared to Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Additionally, bedaquiline demonstrates moderate in vitro activity against non-tuberculous mycobacteria (NTM) species[2].

Bedaquiline exhibits outstanding in vitro activity against Mycobacterium tuberculosis, including strains that are multidrug-resistant[3].

Bedaquiline fumarate/贝达喹啉富马酸盐 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03625739 - Recruiting December 31, 2026 China ... 展开 >> Beijing Children's Hospital of Capital Medical University Recruiting Beijing, China Contact: Adong Shen, Master    13370115087    shenad16@hotmail.com 收起 <<
NCT03474198 Tuberculosis, Pulmonary Phase 2 Phase 3 Recruiting March 12, 2022 Philippines ... 展开 >> De La Salle Health Sciences Institute Not yet recruiting Manila, Philippines Lung Center Philippines Recruiting Manila, Philippines Philippines Tuberculosis Society Incorporated (PTSI) Not yet recruiting Manila, Philippines Tropical Disease Foundation Not yet recruiting Manila, Philippines Singapore National University Hospital Not yet recruiting Singapore, Singapore Thailand King Chulalongkorn Memorial Hospital Not yet recruiting Bangkok, Thailand 收起 <<
NCT00042289 HIV Infections Phase 4 Recruiting September 30, 2019 -

Bedaquiline fumarate/贝达喹啉富马酸盐 参考文献

[1]Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019 Feb 15;29(4):638-645.

[2]Chen X, et al. Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective. J Med Chem. 2021 Aug 12;64(15):10537-10556.

Bedaquiline fumarate/贝达喹啉富马酸盐 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.49mL

0.30mL

0.15mL

7.45mL

1.49mL

0.74mL

14.89mL

2.98mL

1.49mL

Bedaquiline fumarate/贝达喹啉富马酸盐 技术信息

CAS号845533-86-0
分子式C36H35BrN2O6
分子量 671.58
SMILES Code O[C@](CCN(C)C)(C1=C2C=CC=CC2=CC=C1)[C@@H](C3=CC4=CC(Br)=CC=C4N=C3OC)C5=CC=CC=C5.O=C(O)/C=C/C(O)=O
MDL No. MFCD28167761
别名 R403323; TMC207 fumarate; TMC-207; R207910 fumarate; Bedaquiline(fumarate)
运输蓝冰
InChI Key ZLVSPMRFRHMMOY-WWCCMVHESA-N
Pubchem ID 24812732
存储条件

In solvent -20°C: 3-6个月 -80°C: 12个月

Pure form Inert atmosphere, room temperature
溶解方案

DMSO: 105 mg/mL(156.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案 一
方案 二
方案 三
方案 四
方案 五

Tags: Bedaquiline fumarate | R403323;TMC207 fumarate;TMC-207;R207910 fumarate | ATP Synthase | Antibacterial | AmBeed-信号通路专用抑制剂 | Bedaquiline fumarate/贝达喹啉富马酸盐 纯度/质量文件 | Bedaquiline fumarate/贝达喹啉富马酸盐 生物活性 | Bedaquiline fumarate/贝达喹啉富马酸盐 临床数据 | Bedaquiline fumarate/贝达喹啉富马酸盐 参考文献 | Bedaquiline fumarate/贝达喹啉富马酸盐 实验方案 | Bedaquiline fumarate/贝达喹啉富马酸盐 技术信息

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