Research indicates that Avobenzone at an EC50 of 14.1 μM can significantly promote adipogenesis in human bone marrow-derived mesenchymal stem cells (hBM-MSCs), similar to known obesogenic chemicals. At a concentration of 10 μM, it notably increases the mRNA levels of PPARγ, a key regulator of adipogenesis, in these cells^[2].

Additionally, Avobenzone impacts cell proliferation and survival. It inhibits the proliferative activities of human trophoblast cells when applied at concentrations ranging from 1 to 50 μM over a period of 48 hours. In the same concentration range and duration, it also induces apoptosis in HTR8/SVneo cells, a human trophoblast cell line^[3].

Furthermore, Avobenzone demonstrates only weak agonism towards estrogen receptor alpha (ERα) and weak antagonism towards androgen receptor (AR), suggesting its selective interaction with different hormone receptors^[4].