Avobenzone

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Chemical Structure| 70356-09-1 同义名 : BF2AVB; BMDBM; Avobenzone, Avobenzonum, Parsol 1789, Parsol1789, Parsol-1789, HSDB 7423, HSDB-7423, HSDB7423; Butyl methoxydibenzoylmethane
CAS号 : 70356-09-1
货号 : A325409
分子式 : C20H22O3
纯度 : 98%
分子量 : 310.39
MDL号 : MFCD00210252
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(161.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Avobenzone, a dibenzoylmethane derivative, is extensively utilized as a UVA filter in sunscreens to protect the skin from sun damage. It has also been identified as an endocrine disruptor that binds directly to estrogen receptor β, functioning as an estrogen agonist[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.22mL

0.64mL

0.32mL

16.11mL

3.22mL

1.61mL

32.22mL

6.44mL

3.22mL
参考文献

[1]Kojić M, et al. A new insight into the photochemistry of avobenzone in gas phase and acetonitrile from ab initio calculations. Phys Chem Chem Phys. 2016;18(32):22168-22178.

[2]Ahn S, An S, et al. A long-wave UVA filter avobenzone induces obesogenic phenotypes in normal human epidermal keratinocytes and mesenchymal stem cells. Arch Toxicol. 2019;93(7):1903-1915.

[3]Yang C, et al. Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption. Reprod Toxicol. 2018;81:50-57.

[4]Schreurs RH, et al. Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays. Toxicol Sci. 2005;83(2):264-272.